US 6,982,095 B2
Capsules containing vital cells or tissues
Masanori Asada, Osaka (Japan); Yumi Hatano, Osaka (Japan); Ryosei Kamaguchi, Osaka (Japan); and Hideki Sunohara, Osaka (Japan)
Assigned to Morishita Jintan Co., Ltd., Osaka (Japan)
Appl. No. 10/480,720
PCT Filed Jun. 28, 2001, PCT No. PCT/JP01/05606
§ 371(c)(1), (2), (4) Date Dec. 12, 2003,
PCT Pub. No. WO03/001927, PCT Pub. Date Jan. 09, 2003.
Prior Publication US 2004/0175412 A1, Sep. 09, 2004
Int. Cl. A61K 9/14 (2006.01); C12N 1/00 (2006.01); C12N 1/20 (2006.01); C12N 5/02 (2006.01); B29C 47/00 (2006.01)
U.S. Cl. 424—489 3 Claims
OG exemplary drawing
 
1. A seamless capsule in which living cell or tissue is suspended in an aqueous liquid,
wherein the capsule is formed by a seamless capsule manufacturing apparatus with a triple tube nozzle,
wherein the aqueous liquid comprising the living cell or tissue is supplied in an innermost tube of the triple tube nozzle,
wherein a lipophilic material is supplied in a middle tube of the triple tube nozzle,
wherein an outer membrane forming material is supplied in an outermost tube of the triple tube nozzle,
wherein the lipophilic material is selected from the group consisting of deep frying oils, salad oil, vitamin E, wheat germ oil, sesame oil, hardened oil having a melting point of 35° C. or less, cocao butter, butter, margarine, shortening, and fatty acid esters of sucrose,
wherein the outer membrane forming material is at least one natural polymer selected from the group consisting of gelatin, agar, pectin, alginic acid, alginate, carrageenan, curdlan, starch, gellan gum, glucomannan, and mixtures thereof, and
wherein the cell or the tissue can grow in the aqueous liquid.