US 6,982,348 B2
Aminoethanol derivatives
Masakuni Kori, Kobe (Japan); Kazumasa Hamamura, Kawanishi (Japan); Hiromitsu Fuse, Tsukuba (Japan); and Toshihiro Yamamoto, Suita (Japan)
Assigned to Takeda Pharmaceutical Company Limited, Osaka (Japan)
Appl. No. 10/470,351
PCT Filed Jan. 25, 2002, PCT No. PCT/JP02/00532
§ 371(c)(1), (2), (4) Date Jul. 25, 2003,
PCT Pub. No. WO02/059077, PCT Pub. Date Aug. 01, 2002.
Claims priority of application No. 2001-019280 (JP), filed on Jan. 26, 2001.
Prior Publication US 2004/0127574 A1, Jul. 01, 2004
Int. Cl. C07C 233/65 (2006.01); A61K 31/165 (2006.01)
U.S. Cl. 564—158 55 Claims
 
1. A compound represented by the formula
OG Complex Work Unit Drawing
wherein
Ar1 is an aromatic ring group optionally having substituents,
Ar2 is an aromatic ring group having substituents,
OR″ is an optionally protected hydroxyl group,
R is an acyl group, and
R' is a hydrogen atom or a hydrocarbon group optionally having substituents, or a salt thereof;
except tert-butyl benzyl-[2(S)-hydroxy-2-thiazol-2-yl-1(S)-(4-trifluoromethyl-benzyl)-ethyl]-carbamate.