US 6,982,150 B2
System and method for identifying proteins involved in force-initiated signal transduction
Michael P. Sheetz, 560 Riverside Dr., Apt. 7b, New York, N.Y. 10027 (US); and Yasuhiro Sawada, 54 Morningside Dr., Greenwich, Conn. 06830 (US)
Filed on Aug. 10, 2004, as Appl. No. 10/914,924.
Application 10/914924 is a continuation of application No. PCT/US02/15794, filed on May 16, 2002.
Claims priority of provisional application 60/355927, filed on Feb. 11, 2002.
Prior Publication US 2005/0084843 A1, Apr. 21, 2005
Int. Cl. G01N 33/53 (2006.01)
U.S. Cl. 435—7.2 53 Claims
OG exemplary drawing
 
26. A method of identifying proteins involved in mechanotransduction comprising:
providing a cytoskeleton network deficient in force-dependent proteins;
contacting the cytoskeleton network with exogenous proteins,
applying a force to the cytoskeleton network, and
identifying the exogenous proteins that bind to the cytoskeleton network when the force is applied thereto, wherein the exogenous proteins that bind to the cytoskeleton network are identified as proteins involved in mechanotransduction.