US 6,983,176 B2
Optically similar reference samples and related methods for multivariate calibration models used in optical spectroscopy
Craig Gardner, Brookline, Mass. (US); Michael J. Haass, Albuquerque, N. Mex. (US); Robert K. Rowe, Corrales, N. Mex. (US); Howland Jones, Edgewood, N. Mex. (US); Steven T. Strohl, Cedar Crest, N. Mex. (US); Matthew J. Novak, Tucson, Ariz. (US); Russell E. Abbink, Albuquerque, N. Mex. (US); David Nuñez, Sandia Park, N. Mex. (US); William Gruner, Edgewood, N. Mex. (US); and Robert D. Johnson, Albuquerque, N. Mex. (US)
Assigned to Rio Grande Medical Technologies, Inc., Albuquerque, N. Mex. (US)
Filed on Apr. 11, 2001, as Appl. No. 9/832,608.
Prior Publication US 2003/0023170 A1, Jan. 30, 2003
Int. Cl. A61B 5/00 (2006.01)
U.S. Cl. 600—310 86 Claims
OG exemplary drawing
 
1. A reference sample for maintaining prediction performance of an optical system used to measure an analyte or attribute in a representative measurement sample, wherein the representative measurement sample comprises a bodily tissue, bodily fluid or other biological sample containing the analyte or attribute and having a dominant absorbing species therein when in vivo, the reference sample comprising the dominant absorbing species contained and disposed such that an optical signal interrogating the reference sample is subjected to diffuse reflection, where the reference sample and the measurement sample absorb light at each of selected wavelengths in a manner to produce similarly shaped spectra over the wavelengths measured, wherein the reference sample has the spectral characteristics of an in vivo sample.