US 6,982,148 B2
Progressive elevated gene-3 (PEG-3) induces aggressive cancer phenotype and regulates angiogenesis
Paul B. Fisher, Scarsdale, N.Y. (US); and Zao-Zhong Su, New York, N.Y. (US)
Assigned to The Trustees of Columbia University in the City of New York, New York, N.Y. (US)
Filed on Jun. 20, 2002, as Appl. No. 10/177,811.
Application 10/177811 is a continuation of application No. PCT/US00/34564, filed on Dec. 20, 2000.
Claims priority of provisional application 60/173114, filed on Dec. 27, 1999.
Prior Publication US 2003/0044828 A1, Mar. 06, 2003
Int. Cl. C12Q 1/68 (2006.01)
U.S. Cl. 435—6 2 Claims
 
1. A method for identifying a compound which inhibits angiogenesis in a tumor which comprises:
a) contacting a cancer cell with a compound to be tested, wherein the cancer cell normally expresses a PEG3 gene;
b) measuring PEG3 gene expression in the cancer cell;
c) determining whether PEG3 gene expression has been inhibited, wherein inhibition of PEG3 gene expression indicates the identification of a compound which inhibits angiogenesis.