US 6,982,249 B1
Bradykinin analogs as selective inhibitors of cell activation
Alvin H. Schmaier, Ann Arbor, Mich. (US); and Ahmed A. K. Hasan, Dexter, Mich. (US)
Assigned to The Regents of the University of Michigan, Ann Arbor, Mich. (US)
Appl. No. 9/402,732
PCT Filed Apr. 21, 1998, PCT No. PCT/US98/08015
§ 371(c)(1), (2), (4) Date Dec. 01, 1999,
PCT Pub. No. WO98/47522, PCT Pub. Date Oct. 29, 1998.
Claims priority of provisional application 60/046085, filed on Apr. 23, 1997.
Int. Cl. C07K 5/09 (2006.01); C07K 7/00 (2006.01)
U.S. Cl. 514—12 12 Claims
 
1. A method of inhibiting thrombin-induced cell activation mediated by cleavage of a thrombin receptor on said cells comprising administering to an individual in need of such treatment an effective amount of a compound selected from the group consisting of:
(a) Arg-Pro-Pro;
(b) Arg-Pro-Pro-Ala-Phe (SEQ ID NO:6);
(c)
OG Complex Work Unit Drawing
(d)
OG Complex Work Unit Drawing