US 6,982,286 B2 | ||
Carbocyclic hydrazino inhibitors of copper-containing amine oxidases | ||
David John Smith, Naantali (Finland); Ferenc Fülöp, Szeged (Hungary); Marjo Pihlavisto, Kaarina (Finland); László Lázár, Szeged (Hungary); Sakari Alaranta, Raisio (Finland); Petri Vainio, Turku (Finland); and Zsolt Szakonyi, Szeged (Hungary) | ||
Assigned to Biotie Therapies Corp., Turku (Finland) | ||
Filed on Jul. 12, 2001, as Appl. No. 9/902,789. | ||
Prior Publication US 2003/0125360 A1, Jul. 03, 2003 | ||
Int. Cl. A61K 31/135 (2006.01) |
U.S. Cl. 514—657 | 11 Claims |
1. A compound having the Formula I: ![]() or an isomer or a pharmaceutically acceptable solvate, hydrate, or salt thereof;wherein: R1 is hydrogen or (C1-C4)alkyl, aralkyl, (C2-C5)alkanoyl, aroyl or heteroaroyl;
R2 is hydrogen, optionally substituted (C1-C4)alkyl, or optionally substituted aralkyl;
R3-R5 and R10, which can be the same or different, are hydrogen, optionally substituted (C1-C4)alkyl, optionally substituted aralkyl, optionally substituted phenyl or optionally substituted heteroaryl;
R3 and R10 are cis or trans arranged;
R11 is hydrogen, (C1-C4)alkyl, (C2-C5)alkanoyl or aralkyl;
R6-R9, which can be the same or different, are hydrogen, optionally substituted (C1-C4)alkyl, halogen, hydroxy, optionally substituted (C14-C4)alkoxy, optionally substituted aralkyloxy, or (C1-C4)alkylamino;
n is 1 or 3, provided that R1 is not methyl when R2 is methyl, n is 1 and R3 to R11 are hydrogen.
|