US 6,982,362 B1
α-tocopherol transport protein knockout animal
Keizo Inoue, 17-605, Kantozaimukyoku-Ecchujimajyutaku, 1-3, Ecchujima, Koto-ku, Tokyo 135-0044 (Japan); Hiroyuki Arai, 5-35-8-604 Koishikawa, Bunkyo-ku, Tokyo 112-0002 (Japan); Makoto Arita, Kanagawa (Japan); Kou-ichi Jishage, Shizuoka (Japan); and Hiroshi Suzuki, Shizuoka (Japan)
Assigned to Keizo Inoue, Tokyo (Japan); and Hiroyuki Arai,
Appl. No. 10/69,251
PCT Filed Aug. 24, 2000, PCT No. PCT/JP00/05686
§ 371(c)(1), (2), (4) Date Jun. 06, 2002,
PCT Pub. No. WO01/13716, PCT Pub. Date Mar. 01, 2001.
Claims priority of application No. 11/237003 (JP), filed on Aug. 24, 1999.
Int. Cl. A01K 67/027 (2006.01); C12N 15/00 (2006.01)
U.S. Cl. 800—18 7 Claims
 
1. A transgenic mouse whose genome comprises a homozygous disruption of the endogenous α-TTP gene, wherein α-TTP is not expressed and the transgenic mouse does not exhibit detectable plasma levels of α-tocopherol.