US 6,982,274 B2
1H-indazole compound
Hitoshi Oinuma, Ibaraki (Japan); Norihito Ohi, Ibaraki (Japan); Nobuaki Sato, Ibaraki (Japan); Motohiro Soejima, Ibaraki (Japan); Hidenori Seshimo, Saitama (Japan); Taro Terauchi, Ibaraki (Japan); Takashi Doko, Ibaraki (Japan); and Naohiro Kohmura, Ibaraki (Japan)
Assigned to Eisai Co., Ltd., Tokyo (Japan)
Appl. No. 10/469,399
PCT Filed Apr. 15, 2002, PCT No. PCT/JP02/03735
§ 371(c)(1), (2), (4) Date Aug. 28, 2003,
PCT Pub. No. WO02/083648, PCT Pub. Date Oct. 24, 2002.
Claims priority of application No. 2001-116521 (JP), filed on Apr. 16, 2001.
Prior Publication US 2004/0127538 A1, Jul. 01, 2004
Int. Cl. A61K 31/44 (2006.01); C07D 23/56 (2006.01); A61P 25/00 (2006.01)
U.S. Cl. 514—338 18 Claims
 
1. A compound represented by the following formula, a salt thereof or a hydrate thereof:
OG Complex Work Unit Drawing
wherein R1 is a 2-thienyl, 2-furyl, 2-benzofuryl or benzothienyl group thereof, each of which may be substituted;
R2, R4 and R5 each independently represent a halogen atom, a hydroxyl group, a cyano group, a nitro group, a carboxyl group, a C1-C6 alkyl group which may be substituted, a C1-C6 alkoxy group which may be substituted, a C2-C7 acyl group which may be substituted, —CO—NR2aR2b, —NR2bCO—R2a or —NR2aR2b, wherein R2a and R2b each independently represent a hydrogen atom or a C1-C6 alkyl group which may be substituted;
L is a single bond, a C1-C6 alkylene group which may be substituted, a C2-C6 alkenylene group which may be substituted or a C2-C6 alkynylene group which may be substituted;
X is a group represented by —NH—CO—(CH2)t—, wherein t is 0 or 1; and
Y is a hydrogen atom, a halogen atom, a nitro group, a hydroxyl group, a cyano group, a carboxyl group, a C1-C6 alkyl group which may be substituted, a C2-C6 alkenyl group which may be substituted, a C2-C6 alkynyl group which may be substituted, a C1-C6 alkoxy group which may be substituted, a C3-C8 cycloalkyl group which may be substituted, a C3-C8 cycloalkenyl group which may be substituted, a C6-C14 aromatic cyclic hydrocarbon group which may be substituted, an amino group or —W—R15, wherein W is —CO— or —SO2—; and R15 is a C1-C6 alkyl group which may be substituted, a C6-C14 aromatic cyclic hydrocarbon group which may be substituted.