US 6,982,284 B1
Compositions and methods for modification of skin lipid content
David A. Brown, Merrick, N.Y. (US); and Daniel B. Yarosh, Merrick, N.Y. (US)
Assigned to Applied Genetics Incorporated Dermatics, Freeport, N.Y. (US)
Appl. No. 10/70,466
PCT Filed Sep. 08, 2000, PCT No. PCT/US00/24659
§ 371(c)(1), (2), (4) Date Mar. 07, 2002,
PCT Pub. No. WO01/17523, PCT Pub. Date Mar. 15, 2001.
Claims priority of provisional application 60/153378, filed on Sep. 10, 1999.
Int. Cl. A61K 31/185 (2006.01); A61K 31/20 (2006.01); A61K 31/56 (2006.01)
U.S. Cl. 514—577 17 Claims
 
1. A method for increasing the lipid content of the epidermal keratinocytes of the skin of a mammal in need of said increase comprising topically administering a ursolic acid compound encapsulated in liposomes to said skin in an amount effective to increase the lipid content of said epidermal keratinocytes, said liposomes comprising phospholipid bilayer membranes, wherein said increase in lipid content comprises an increase in at least one member of the ceramide lipid family.