US 6,982,346 B2
Process of making D-panthenyl triacetate
Jon Kirk Smith, Marion, Mass. (US); Zongzheng Liu, Fall River, Mass. (US); Murugappa Vedachalam, Raynham, Mass. (US); and David Compton, Waquoit, Mass. (US)
Assigned to ISP Investments Inc., Wilmington, Del. (US)
Filed on Jul. 01, 2003, as Appl. No. 10/611,095.
Prior Publication US 2005/0002972 A1, Jan. 06, 2005
Int. Cl. C07C 69/34 (2006.01); C07C 69/52 (2006.01); C07C 67/36 (2006.01)
U.S. Cl. 560—190 8 Claims
 
1. A process of making D-panthenyl triacetate comprising the steps of:
a) esterifying D-panthenol in the presence of acetic anhydride and polymer bound dimethylaminopyridine which form an exothermic mixture;
b) heating the exothermic mixture for a sufficient time to complete the reaction;
c) removing the acetic acid formed in the exothermic mixture by distillation;
d) removing the polymer bound dimethylaminopyridine by filtration;
e) neutralizing the exothermic mixture with a sodium hydroxide solution to precipitate sodium acetate; and
f) removing the precipitated sodium acetate by filtration.