US 6,982,249 B1 | ||
Bradykinin analogs as selective inhibitors of cell activation | ||
Alvin H. Schmaier, Ann Arbor, Mich. (US); and Ahmed A. K. Hasan, Dexter, Mich. (US) | ||
Assigned to The Regents of the University of Michigan, Ann Arbor, Mich. (US) | ||
Appl. No. 9/402,732 PCT Filed Apr. 21, 1998, PCT No. PCT/US98/08015 § 371(c)(1), (2), (4) Date Dec. 01, 1999, PCT Pub. No. WO98/47522, PCT Pub. Date Oct. 29, 1998. |
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Claims priority of provisional application 60/046085, filed on Apr. 23, 1997. | ||
Int. Cl. C07K 5/09 (2006.01); C07K 7/00 (2006.01) |
U.S. Cl. 514—12 | 12 Claims |
1. A method of inhibiting thrombin-induced cell activation mediated by cleavage of a thrombin receptor on said cells comprising
administering to an individual in need of such treatment an effective amount of a compound selected from the group consisting
of:
(a) Arg-Pro-Pro;
(b) Arg-Pro-Pro-Ala-Phe (SEQ ID NO:6);
(c)
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