US 6,982,321 B2
Altered antibodies
Gregory Paul Winter, Cambridge (United Kingdom)
Assigned to Medical Research Council, London (United Kingdom); and BTG International Limited, London (United Kingdom)
Filed on Jan. 24, 2003, as Appl. No. 10/351,748.
Application 10/351748 is a continuation of application No. 08/452462, filed on May 26, 1995, granted, now 6,548,640.
Application 08/452462 is a continuation of application No. 07/942140, filed on Sep. 09, 1992, abandoned.
Application 07/942140 is a continuation of application No. 07/624515, filed on Dec. 07, 1990, abandoned.
Application 07/624515 is a continuation of application No. 07/189814, filed on May 03, 1988, abandoned.
Prior Publication US 2004/0127688 A1, Jul. 01, 2004
Prior Publication US 2004/0192897 A2, Sep. 30, 2004
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 16/00 (2006.01)
U.S. Cl. 530—387.3 24 Claims
 
1. An antibody comprising a human kappa light chain variable domain, wherein said light chain variable domain comprises a set of tour human Kabat framework regions (FRs), wherein each of said FRs in said set of four FRs comprises residues identical to the most common residue in each position in a Kabat alignment of a human kappa sub-group 1, and wherein said antibody binds an antigen.