US 6,982,142 B2 | ||
Methods for screening therapeutically effective agents | ||
Myles C. Cabot, Santa Monica, Calif. (US) | ||
Assigned to John Wayne Cancer Institute, Santa Monica, Calif. (US) | ||
Filed on Nov. 30, 1998, as Appl. No. 9/201,115. | ||
Claims priority of provisional application 60/067489, filed on Dec. 01, 1997. | ||
Prior Publication US 2002/0160354 A1, Oct. 31, 2002 | ||
This patent is subject to a terminal disclaimer. | ||
Int. Cl. G01N 33/50 (2006.01); G01N 33/53 (2006.01); G01N 33/92 (2006.01); C12Q 1/68 (2006.01) |
U.S. Cl. 435—4 | 7 Claims |
1. A method for assessing the therapeutic potential of a chemotherapeutic agent in a combination with a chemosensitizer for
treating a disease, said method comprising:
(a) contacting cells expressing glucosylceramide synthase (GCS) with a combination of at least one chemotherapeutic agent
and at least one chemosensitizer; and
(b) measuring the activity of GCS in said cells, wherein a decrease in said GCS activity indicates therapeutic potential of
said combination in treating said disease.
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