US 6,982,154 B2
Modified annexin proteins and methods for treating vaso-occlusive sickle-cell disease
Anthony Allison, Belmont, Calif. (US)
Assigned to Surromed, Inc., Menlo Park, Calif. (US)
Filed on Aug. 01, 2003, as Appl. No. 10/632,694.
Application 10/632694 is a continuation in part of application No. 10/080370, filed on Feb. 21, 2002.
Claims priority of provisional application 60/400718, filed on Aug. 02, 2002.
Prior Publication US 2004/0086515 A1, May 06, 2004
Int. Cl. A61K 38/17 (2006.01); A61K 39/395 (2006.01); C12P 21/06 (2006.01)
U.S. Cl. 435—69.1 11 Claims
 
1. A method for treating sickle-cell disease in a subject, comprising administering to said subject a pharmaceutical composition comprising a therapeutically effective amount of a modified annexin protein, wherein said modified annexin protein comprises a first annexin protein coupled to a second annexin protein, wherein the sickle-cell disease is treated.