US 6,982,350 B2
Process for the synthesis of (1S)-4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutane and addition salts thereof, and to the application thereof in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
Jean-Michel Lerestif, Yvetot (France); Isaac Gonzalez Blanco, Toledo (Spain); Jean-Pierre Lecouve, Le Havre (France); and Daniel Brigot, Saint-Marie-des-Champs (France)
Assigned to Les Laboratoires Servier, Courbevoie Cedex (France)
Filed on Feb. 17, 2005, as Appl. No. 11/60,011.
Claims priority of application No. 04 05453 (FR), filed on May 19, 2004.
Prior Publication US 2005/0261376 A1, Nov. 24, 2005
Int. Cl. C07B 57/00 (2006.01)
U.S. Cl. 564—304 15 Claims
 
1. A process for the resolution of a compound of formula (IV):
OG Complex Work Unit Drawing
wherein the compound of formula (IV) is reacted with an optically active diacidic compound,followed by filtration, or filtration under suction, of the suspension thereby obtained,to yield a compound of formula (VII):
OG Complex Work Unit Drawing
which is reacted with a base to yield a compound of formula (VIII) having configuration (S):
OG Complex Work Unit Drawing