US 6,982,317 B2 | ||
C21 polypeptide that modulates the stability of transcriptional regulatory complexes regulating nuclear hormone receptor activity | ||
Ross S. Basch, New York, N.Y. (US); and Xin-Min Zhang, Bronx, N.Y. (US) | ||
Assigned to New York University, New York, N.Y. (US) | ||
Filed on Nov. 15, 2001, as Appl. No. 9/987,701. | ||
Claims priority of provisional application 60/248191, filed on Nov. 15, 2000. | ||
Prior Publication US 2005/0119456 A1, Jun. 02, 2005 | ||
Int. Cl. C07K 14/47 (2006.01); C07K 16/18 (2006.01) |
U.S. Cl. 530—350 | 7 Claims |
1. An isolated polypeptide which interacts with, and has the activity of modulating the stability of transcriptional regulatory complexes that regulate nuclear hormone receptor activity, comprising an amino acid sequence of SEQ ID NO:2, or a fragment or variant thereof, wherein said fragment retains the activity of the polypeptide and said variant comprises an amino acid sequence having at least 90% sequence identity with SEQ ID NO:2 and has the activity of modulating the stability of transcriptional regulatory complexes that regulate nuclear hormone receptor activity. |