US 6,982,261 B2 | ||
Cyanopyrroles | ||
Mark A. Collins, Norristown, Pa. (US); Valerie A. Mackner, Conshohocken, Pa. (US); Jay E. Wrobel, Lawrenceville, N.J. (US); Lin Zhi, San Diego, Calif. (US); Todd K. Jones, Solana Beach, Calif. (US); James P. Edwards, San Diego, Calif. (US); and Christopher M. Tegley, Thousand Oaks, Calif. (US) | ||
Assigned to Wyeth, Madison, N.J. (US); and Ligand Pharmaceuticals, Inc., San Diego, Calif. (US) | ||
Filed on Jan. 15, 2003, as Appl. No. 10/342,719. | ||
Application 10/342719 is a division of application No. 10/043513, filed on Jan. 09, 2002, granted, now 6,562,857. | ||
Application 10/043513 is a division of application No. 09/552544, filed on Apr. 19, 2000, granted, now 6,407,161. | ||
Claims priority of provisional application 60/183050, filed on May 04, 1999. | ||
Prior Publication US 2003/0158182 A1, Aug. 21, 2003 | ||
Int. Cl. A61K 31/54 (2006.01); A01K 31/535 (2006.01); C07D 279/16 (2006.01); C07D 498/00 (2006.01) |
U.S. Cl. 514—224.2 | 4 Claims |
1. A compound having the structure of formula 1:![]() wherein: T is S;
R1 and R2 are each, independently, hydrogen, alkyl, or substituted alkyl; or
R1 and R2 are taken together to form a ring selected from the group consisting of —CH2(CH2)nCH2—, —CH2CH2C(CH3)2CH2CH2—, —O(CH2)pCH2—, —O(CH2)qO—, —CH2CH2OCH2CH2—, and —CH2CH2NR7CH2CH2—;
n=1–5;
p=1–4;
q=1–4;
R3 is hydrogen, OH, NH2, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, or CORA;
RA is hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aminoalkyl, or substituted aminoalkyl;
R4 is hydrogen, halogen, CN, NH2, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aminoalkyl, or substituted aminoalkyl;
R5 is hydrogen, alkyl, or substituted alkyl;
R6 is hydrogen, alkyl, substituted alkyl, or CORB;
RB is hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aminoalkyl, or substituted aminoalkyl;
R7 is hydrogen or alkyl;
or a pharmaceutically acceptable salt thereof.
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