US 6,982,324 B1
Degradable macromolecular magnetic resonance imaging contrast agents and methods thereof
Zheng-Rong Lu, Salt Lake City, Utah (US); Jindrich Kopecek, Salt Lake City, Utah (US); and Dennis L. Parker, Centerville, Utah (US)
Assigned to University of Utah Research Foundation, Salt Lake City, Utah (US)
Filed on Nov. 05, 2002, as Appl. No. 10/288,618.
Claims priority of provisional application 60/338831, filed on Nov. 13, 2001.
Int. Cl. C07F 5/00 (2006.01)
U.S. Cl. 534—15 6 Claims
 
1. A macromolecule contrast agent comprising a compound according to the following formula:
OG Complex Work Unit Drawing
wherein R and R′ are independently selected from the group consisting of C1 to C18 alkyls, substituted alkyls, aryls, polyethylene glycol, saccharides, amino acids, peptides, proteins, peptide conjugates and protein conjugates, and combinations of alkyl, aryl and polyethylene glycol;
wherein X and Y are independently selected from the group consisting of O and NH; and
wherein n is an integer between 2 and 10,000.