US 6,982,283 B2 | ||
Method for treating drug-induced constipation | ||
Ryuji Ueno, Montgomery, Md. (US) | ||
Assigned to Sucampo AG, Zug (Switzerland) | ||
Filed on May 01, 2002, as Appl. No. 10/135,397. | ||
Claims priority of provisional application 60/287720, filed on May 02, 2001. | ||
Prior Publication US 2003/0073746 A1, Apr. 17, 2003 | ||
Int. Cl. A61K 31/557 (2006.01); A61K 31/19 (2006.01) |
U.S. Cl. 514—530 | 12 Claims |
1. A method for treating drug-induced constipation comprising a step of administering an effective amount of 15-keto-prostaglandin
compound to a subject suffering from drug-induced constipation or in need thereof of such treatment, wherein the 15-keto-prostaglandin
compound is one represented by formula (I): ![]() wherein L,M and N are hydrogen, hydroxy, halogen, lower alkyl, hydroxy(lower)alkyl or oxo, wherein at least one of L and M is a group
other than hydrogen, and the five-membered ring may have at least one double bond;
A is —CH2OH, —COCH2OH, —COOH or a functional derivative thereof;
B is —CH2—CH2—, —CH═CH— or —C≡C—;
R1 is a saturated or unsaturated bivalent lower or medium aliphatic hydrocarbon residue, which is unsubstituted or substituted
with halogen, alkyl, hydroxy, oxo, aryl or heterocyclic group and at least one carbon atom in the aliphatic hydrocarbon is
optionally substituted by oxygen, nitrogen or sulfur; and
Ra is a saturated or unsaturated lower or medium aliphatic hydrocarbon residue, which is unsubstituted or substituted with
halogen, oxo, hydroxy, lower alkoxy, lower alkanoyloxy, cyclo(lower)alkyl, cyclo(lower)alkyloxy, aryl, aryloxy, heterocyclic
group or heterocyclic-oxy group; cyclo(lower)alkyl; cyclo(lower)alkyloxy; aryl; aryloxy; heterocyclic group; heterocyclic-oxy
group.
|