US 6,982,280 B1
Epothilone derivatives, a method for the production thereof, and their use
Gerhard Hoefle, Mascheroder Weg 1, D-38124 Braunschweig (Germany); and Thomas Leibold, Mascheroder Weg 1, D-38124 Braunschweig (Germany)
Appl. No. 9/674,877
PCT Filed May 07, 1999, PCT No. PCT/EP99/03159
§ 371(c)(1), (2), (4) Date Jan. 02, 2001,
PCT Pub. No. WO99/58534, PCT Pub. Date Nov. 18, 1999.
Claims priority of application No. 198 20 599 (DE), filed on May 08, 1998.
Int. Cl. A61K 31/365 (2006.01); C07D 493/02 (2006.01)
U.S. Cl. 514—450 21 Claims
 
1. A compound of the formula:
OG Complex Work Unit Drawing
wherein
R1 is a H atom or a C1- to C8-alkyl group,
X—Y is a group of the formula —CH2CH(OP)— or —CH═CH—, and
P is a protecting group.