US 6,982,271 B1
Tropane analogs
Alan P. Kozikowski, Princeton, N.J. (US); and Wolfgang Alexander Hoepping, Dresden (Germany)
Assigned to Georgetown University, Washington, D.C. (US)
Filed on Sep. 27, 2000, as Appl. No. 9/671,104.
Claims priority of provisional application 60/156275, filed on Sep. 27, 1999.
Int. Cl. A61K 31/46 (2006.01); C07D 471/18 (2006.01); A61P 25/00 (2006.01)
U.S. Cl. 514—295 16 Claims
 
1. A compound represented by formula (II):
OG Complex Work Unit Drawing
wherein,
R1 and R2 each independently are selected from the group consisting of hydrogen, aryl, and heteroaryl,
R3-R13 are hydrogen;
R14 is selected from the group consisting of —R16C(O)OR15, —OC(O)R15, —O—R17, wherein R17 is selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, alkenyl, and alkynyl; —R16(O)CR15; —C(R15)═N(OH); carboxylic acid; —R16C(O)H; -Q2-P(Q1)(OR15)2; and silyl;
R15 represents independently for each occurrence hydrogen, alkyl, alkenyl, alkynyl, or aryl;
R16 represents independently for each occurrence a bond or an alkyl, alkenyl, alkynyl, or aryl biradical;
Q1 represents independently for each occurrence S or O; and
Q2 represents independently for each occurrence O, S, or NR15;
or a pharmaceutically acceptable salt thereof.