US 7,320,998 B1
Carbohydrate analog inhibitors of alpha-amylase
Stephen S. Rothman, Berkeley, Calif. (US); and Edmund J. Niedzinskl, Berkeley, Calif. (US)
Assigned to Chymos Corporation, Berkeley, Calif. (US)
Filed on Jul. 09, 2004, as Appl. No. 10/888,480.
Claims priority of provisional application 60/487081, filed on Jul. 11, 2003.
Int. Cl. A61K 31/225 (2006.01); C07C 67/02 (2006.01); C07C 211/00 (2006.01)
U.S. Cl. 514—548  [560/251; 560/252; 564/457] 32 Claims
 
1. A method of reducing caloric utilization in a human comprised of orally administering to the human an α-amylase inhibitory effective amount of a bicyclohexane derivative having an in vitro IC50 of less than 1×10−4 M toward human pancreatic or salivary α-amylase enzyme.