US 7,321,029 B2
2′-arabino-fluorooligonucleotide N3′→P5′ phosphoramidates: their synthesis and use
Sergei Gryaznov, San Mateo, Calif. (US); and Ronald G. Schultz, Urbana, Mo. (US)
Assigned to Geron Corporation, Menlo Park, Calif. (US)
Appl. No. 10/181,823
PCT Filed Jan. 19, 2001, PCT No. PCT/US01/01918
§ 371(c)(1), (2), (4) Date May 29, 2003,
PCT Pub. No. WO01/53307, PCT Pub. Date Jul. 26, 2001.
Claims priority of provisional application 60/178248, filed on Jan. 21, 2000.
Prior Publication US 2004/0126752 A1, Jul. 01, 2004
Int. Cl. C07H 21/00 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01); C12Q 1/68 (2006.01); C07G 3/00 (2006.01)
U.S. Cl. 536—23.1  [536/24.3; 536/25.3; 536/26.6; 536/4.1; 435/6] 20 Claims
OG exemplary drawing
 
1. A polynucleotide comprising at least one 2′-arabino-fluoronucleoside linked to at least one additional nucleoside subunit by a linkage selected from the group consisting of N3′→P5′ phosphoramidate and N3′→P5′ thiophosphoramidate intersubunit linkages.