US 7,321,050 B2 | ||
Anti-inflammatory and psoriasis treatment and protein kinase inhibition by hydroxy stilbenes and novel stilbene derivatives and analogues | ||
Genhui Chen, Burnaby (Canada); John M. Webster, North Vancouver (Canada); Jianxiong Li, Port Moody (Canada); Kaji Hu, Burnaby (Canada); Wei Liu, Coquitlam (Canada); and Jiang Zhu, Burnaby (Canada) | ||
Assigned to Welichem Biotech Inc., Burnaby, BC (Canada) | ||
Filed on Jul. 15, 2004, as Appl. No. 10/893,863. | ||
Application 10/893863 is a continuation in part of application No. 10/148863, filed on Oct. 28, 2002, abandoned. | ||
Application 10/148863 is a continuation in part of application No. PCT/CA03/01497, filed on Sep. 30, 2003. | ||
Claims priority of provisional application 60/414632, filed on Oct. 01, 2002. | ||
Claims priority of provisional application 60/414633, filed on Oct. 01, 2002. | ||
Prior Publication US 2005/0059733 A1, Mar. 17, 2005 | ||
Int. Cl. C07C 69/76 (2006.01); C07C 62/00 (2006.01); C07C 39/12 (2006.01); C07C 19/00 (2006.01) |
U.S. Cl. 560—64 [562/466; 568/717; 570/129] | 18 Claims |
1. A compound of the following formula, or a salt thereof
![]() R1 is selected from the group consisting of unsubstituted or substituted alkyl with carbon between 1 and 18; alkenyl with carbon
between 2 and 18; alkynyl with carbon between 2 and 18; halo, and COR9;
R2 and R3 are independently selected from the group consisting of H, unsubstituted or substituted alkyl with carbon between 1 and 18,
and acyl with carbon between 1 and 18;
R4, R5, R6, R7 and R8 are independently selected from the group consisting of H, unsubstituted or substituted alkyl with carbon between 1 and 18,
alkenyl with carbon between 2 and 18, alkynyl with carbon between 2 and 18, aryl or aralkyl group, chloro, bromo, iodo, fluoro,
nitro, CN, COR9, NR10R11, S(O)2NR10R11, SR10, SOR10, SO2R10, and OR12; with the proviso that at least one of R4, R5, R6, R7, and R8 is fluoro;
R9 is selected from H, unsubstituted or substituted alkyl, cycloalkyl, aryl, or aralkyl, or NR10R11, or OR10;
R10 and R11 are selected from H, unsubstituted or substituted alkyl, cycloalkyl, aryl and aralkyl;
R12 is selected from H, unsubstituted or substituted alkyl, cycloalkyl, aryl, aralkyl and acyl; and
wherein the configuration of the double bond of the compound of Formula I is E or Z.
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