US 7,320,679 B2
Therapeutic use of growth factor, and delivery device, especially for the treatment of intimal hyperplasia
John Francis Martin, London (United Kingdom); Seppo Yla-Herttuala, Kuopio (Finland); and Stephen George Edward Barker, London (United Kingdom)
Assigned to Ark Therapeutics, Ltd., (United Kingdom)
Filed on Feb. 19, 2003, as Appl. No. 10/370,291.
Application 10/370291 is a continuation of application No. 09/297486, previously published as PCT/GB97/03015, filed on Nov. 03, 1997.
Claims priority of application No. 9622852.3 (GB), filed on Nov. 01, 1996; application No. 9709494.0 (GB), filed on May 09, 1997; and application No. 9717791.9 (GB), filed on Aug. 21, 1997.
Prior Publication US 2003/0225020 A1, Dec. 04, 2003
Int. Cl. A61M 31/00 (2006.01); A61M 5/00 (2006.01)
U.S. Cl. 604—93.01  [604/95.03; 604/264] 29 Claims
 
1. A device for use in the delivery of a therapeutic agent to a blood vessel in a patient, which comprises a body composed of a biodegradable material and adapted to provide a continuous seal around the vessel, the body having a wall which, with an adventitial surface of the vessel, defines a reservoir within which the agent is held and comes into contact with the adventitial surface of the vessel, wherein the reservoir is at least part-filled by a pharmaceutical formulation containing the agent to be delivered, and wherein the body material has a thickness that is smaller in an intermediate portion of the body than at spaced-apart portions of the body that seal against the vessel, the reduced thickness forming the reservoir.