US 7,320,962 B2
Hemoactive compositions and methods for their manufacture and use
Cary J. Reich, Sierra Madre, Calif. (US); A. Edward Osawa, San Francisco, Calif. (US); and Helen Tran, San Jose, Calif. (US)
Assigned to Baxter International Inc., Deerfield, Ill. (US); and Baxter Healthcare S.A., Zurich (Switzerland)
Filed on Jan. 20, 2004, as Appl. No. 10/761,922.
Application 10/761922 is a continuation in part of application No. 09/553969, filed on Apr. 21, 2000.
Application 09/553969 is a continuation in part of application No. 09/330315, filed on Jun. 10, 1999, granted, now 6,706,690, filed on Mar. 16, 2004.
Application 09/330315 is a continuation of application No. 09/032370, filed on Feb. 27, 1998, granted, now 6,066,325, filed on May 23, 2000.
Application 09/032370 is a continuation in part of application No. 08/903674, filed on Jul. 31, 1997, granted, now 6,063,061, filed on May 16, 2000.
Application 08/903674 is a continuation in part of application No. 08/704852, filed on Aug. 27, 1996, abandoned.
Claims priority of provisional application 60/050437, filed on Jun. 18, 1997.
Prior Publication US 2004/0214770 A1, Oct. 28, 2004
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 38/17 (2006.01); A61K 31/74 (2006.01); A61K 35/14 (2006.01); A61K 9/00 (2006.01)
U.S. Cl. 514—21  [514/54; 514/60; 514/777; 514/944; 530/354; 530/356; 530/380; 530/402; 424/78.02; 424/78.06; 424/478; 435/810] 29 Claims
 
1. A dried hemoactive material for inhibiting bleeding or delivering an agent, comprising:
a cross-linked biologically compatible polymer which forms a hydrogel when exposed to blood; and
a non-cross-linked biologically compatible polymer which solubilizes when exposed to blood:
wherein the cross-linked polymer is dispersed in a dried matrix of the non-cross-linked polymer.