US RE40,023 E1
Dietary and pharmaceutical compositions containing lyophilized lactic bacteria, their preparation and use
Claudio DeSimone, Via Fabretti, 8, 00161 Roma (Italy)
Filed on Mar. 15, 2006, as Appl. No. 11/375,704.
Application 08/448787 is a continuation of application No. 08/117751, filed on Sep. 08, 1993, abandoned.
Application 08/117751 is a continuation in part of application No. 07/983839, filed on Dec. 01, 1992, abandoned.
Application 11/375704 is a reissue of application No. 08/448787, filed on May 24, 1995, now 5,716,615, filed on Feb. 10, 1998.
Claims priority of application No. MI92A0256 (IT), filed on Feb. 10, 1992.
Int. Cl. A61K 38/44 (2006.01); C12N 1/04 (2006.01); C12N 1/20 (2006.01)
U.S. Cl. 424—93.4  [424/93.44; 424/93.45; 426/61; 435/252.4; 435/252.9; 435/253.4; 435/260; 435/856; 435/885] 33 Claims
 
1. A pharmaceutical composition comprising:
a) from 10% to 95% by weight of total composition of lyophilized Streptococcus thermophilus, and
b) from 5% to 90% by weight of total composition of at least one lyophilized bacterium selected from the group consisting of Lactobacillus plantarum and Lactobacillus casei, and
c) from 0% to 10% by weight of total composition a pharmaceutically acceptable excipient,
wherein said Streptococcus thermophilus and the bacterium b) are present in a concentration of 1×1011-1×1013 total bacteria per gram of the composition.