US 7,320,675 B2 | ||
Method and apparatus for modulating cellular metabolism during post-ischemia or heart failure | ||
Joseph M. Pastore, Minneapolis, Minn. (US); Julio C. Spinelli, Shoreview, Minn. (US); Helen L. Reeve, St. Paul, Minn. (US); Jeffrey Ross, Roseville, Minn. (US); Rodney W. Salo, Fridley, Minn. (US); and Allan Shuros, St. Paul, Minn. (US) | ||
Assigned to Cardiac Pacemakers, Inc., St. Paul, Minn. (US) | ||
Filed on Aug. 21, 2003, as Appl. No. 10/645,823. | ||
Prior Publication US 2005/0043675 A1, Feb. 24, 2005 | ||
Int. Cl. A61M 31/00 (2006.01) |
U.S. Cl. 604—67 | 43 Claims |
1. A system, comprising:
an implantable metabolic sensor to sense a metabolic signal indicative of a cardiac metabolic level;
an implantable processor coupled to the implantable metabolic sensor, the implantable processor including:
a metabolic sensor processing circuit to determine the cardiac metabolic level from the metabolic signal; and
a drug delivery controller to produce a drug delivery signal based on the cardiac metabolic level; and
an implantable drug delivery device, communicatively coupled to the implantable processor, to deliver a drug based on the
drug delivery signal, the implantable drug delivery device including a drug reservoir storing a drug shifting a source of
metabolically synthesized energy for cardiac contractions from fatty acid to glucose.
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