US 7,320,990 B2
Crystalline form of a biphenyl compound
Robert Chao, Santa Clara, Calif. (US); Miroslav Rapta, Sunnyvale, Calif. (US); Pierre-Jean Colson, San Francisco, Calif. (US); and Junning Lee, El Granada, Calif. (US)
Assigned to Theravance, Inc., South San Francisco, Calif. (US)
Filed on Feb. 11, 2005, as Appl. No. 11/57,009.
Claims priority of provisional application 60/544621, filed on Feb. 13, 2004.
Prior Publication US 2005/0182092 A1, Aug. 18, 2005
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 211/56 (2006.01); C07D 211/72 (2006.01); A61K 31/47 (2006.01)
U.S. Cl. 514—317  [546/224; 546/304; 546/312] 21 Claims
 
1. A crystalline naphthalene-1,5-disulfonic acid salt of biphenyl-2-ylcarbamic acid 1-{9-[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydro-quinolin-5-yl)ethylamino]nonyl}piperidin-4-yl ester or a solvate thereof.