US 7,320,880 B2
Polypeptide having an activity to support proliferation or survival of hematopoietic stem cell and hematopoietic progenitor cell, and DNA coding for the same
Mitsuo Nishikawa, Gunma (Japan); Radoje T. Drmanac, Los Altos Hills, Calif. (US); Ivan Lobal, Mountain View, Calif. (US); Y. Tom Tang, San Jose, Calif. (US); Juhi Lee, San Diego, Calif. (US); and Birgit Stache-Crain, San Jose, Calif. (US)
Assigned to Nuvelo, Inc., San Carlos, Calif. (US); and Kirin Beer Kabushiki Kaisha, Tokyo (Japan)
Appl. No. 10/478,926
PCT Filed Jun. 11, 2002, PCT No. PCT/JP02/05807
§ 371(c)(1), (2), (4) Date Jun. 17, 2004,
PCT Pub. No. WO02/100898, PCT Pub. Date Dec. 19, 2002.
Claims priority of provisional application 60/297286, filed on Jun. 11, 2001.
Prior Publication US 2004/0220396 A1, Nov. 04, 2004
Int. Cl. C07H 21/04 (2006.01); C07K 14/475 (2006.01); C12N 5/00 (2006.01); C12N 1/00 (2006.01); C12P 21/02 (2006.01)
U.S. Cl. 435—69.1  [435/70.1; 435/252.3; 435/320.1; 435/325; 435/375; 530/350; 530/399; 536/23.5] 10 Claims
 
1. An isolated DNA molecule, wherein the DNA molecule comprises (a) the nucleotide sequence of nucleotides 630 to 1358 of SEQ ID NO: 22, or (b) a nucleotide sequence that hybridizes thereto under one of the following stringent conditions:
(1) wash in 6×SSC, 5×Denhardt, 0.5% SDS at 68° C.; or
(2) wash in 6×SSC, 5×Denhardt, 0.5% SDS 50% formamide at 42° C.;
and wherein the nucleotide sequence encodes a polypeptide having an activity to support proliferation of erythroid progenitor cells.