US 7,320,985 B2 | ||
Method for stabilizing arylcarboxylic acid, stabilizer thereof and aqueous solution containing stabilized arylcarboxylic acid | ||
Shirou Sawa, Kobe (Japan) | ||
Assigned to Senju Pharmaceutical Co., Ltd., Osaka (Japan) | ||
Filed on Jul. 23, 2003, as Appl. No. 10/624,674. | ||
Application 09/885096 is a division of application No. 09/017626, filed on Feb. 02, 1998, granted, now 6,274,592. | ||
Application 10/624674 is a continuation of application No. 09/885096, filed on Jun. 21, 2001, abandoned. | ||
Claims priority of application No. 9-21805 (JP), filed on Feb. 04, 1997. | ||
Prior Publication US 2005/0075350 A1, Apr. 07, 2005 | ||
Int. Cl. A61K 31/436 (2006.01); A61K 31/495 (2006.01); A61K 31/52 (2006.01); A61K 47/22 (2006.01) |
U.S. Cl. 514—291 [514/230.5; 514/253.04; 514/253.08; 514/264; 514/300; 514/312; 514/352; 514/365; 514/420; 514/567; 514/226.2; 546/89; 546/311; 546/204; 546/500; 546/501; 544/38] | 4 Claims |
1. A method for stabilizing an arylcarboxylic acid or a pharmacologically acceptable salt thereof in an aqueous solution,
which comprises adding a pyridonecarboxylic acid selected from
(a) a pyridonecarboxylic acid of the formula (IV):
![]() wherein
X is a carbon atom; and
R12, R13, R14 and R15 are the same or different and each is a hydrogen atom, a halogen, a carboxyl group, an optionally substituted lower alkyl
group, an optionally substituted cycloalkyl group, an optionally substituted acyl group, an optionally substituted aryl group
or an optionally substituted heterocyclic group;
wherein R12 and R13 optionally form a 4- to 6-membered heterocyclic group with the adjacent nitrogen atom and X, and R14 and R15 optionally form a 4- to 6-membered heterocyclic group with the adjacent carbon atom,
(b) cinoxacin or
(c) sparfioxacin,
or a pharmacologically acceptable salt thereof,
to an arylcarboxylic acid of the formula (I):
L1-R1COOH (I)
wherein
L1 is an optionally substituted aryl group having not more than 14 carbon atoms; and
R1 is an optionally substituted alkyl group having not more than 4 carbon atoms or a single bond,
or a pharmacologically acceptable salt thereof.
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