US 7,320,997 B2
Pharmaceutical compositions including carotenoid ester analogs or derivatives for the inhibition and amelioration of disease
Samuel Fournier Lockwood, Lake Linden, Mich. (US); Sean O'Malley, Honolulu, Hi. (US); David G. Watumull, Honolulu, Hi. (US); Laura M. Hix, San Francisco, Calif. (US); Henry Jackson, Honolulu, Hi. (US); and Geoff Nadolski, Kaaawa, Hi. (US)
Assigned to Cardax Pharmaceuticals, Inc., Aiea, Hi. (US)
Filed on Mar. 04, 2004, as Appl. No. 10/793,692.
Application 10/793692 is a continuation in part of application No. 10/629538, filed on Jul. 29, 2003.
Claims priority of provisional application 60/485304, filed on Jul. 03, 2003.
Claims priority of provisional application 60/473741, filed on May 28, 2003.
Claims priority of provisional application 60/472831, filed on May 22, 2003.
Claims priority of provisional application 60/467973, filed on May 05, 2003.
Claims priority of provisional application 60/399194, filed on Jul. 29, 2002.
Prior Publication US 2005/0075316 A1, Apr. 07, 2005
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/341 (2006.01)
U.S. Cl. 514—473 74 Claims
 
1. A pharmaceutical composition comprising:
a carotenoid analog or derivative having the structure

OG Complex Work Unit Drawing
where each R3 is independently hydrogen or methyl;
where each Y is independently O or H2;
where each R is independently OR1 or R1;
where each R1 is independently -alkyl-NR23+, -alkyl-NR22, -aryl-NR23+, -alkyl-CO2, -aryl-CO2, -alkyl-CO2H, -alkyl-CO2R6, -alkyl-CO2R7, —OR7, -amino acid-NH2, -amino acid-NH3+, -phosphorylated amino acid-NH3+, polyethylene glycol, dextran, H, alkyl, aryl, -alkyl-O—PO2-O—alkyl-NR23+,

OG Complex Work Unit Drawing
where each R2 is independently H, alkyl, or aryl;
wherein R′ is alkyl-O, alkyl, or aryl;
wherein each R5 is independently H, alkyl, benzyl, or alkali salt;
wherein R6 is alkyl, —CH2—CH(OH)—CH2—O—PO2—O-alkyl-NR23+,

OG Complex Work Unit Drawing
wherein R7 is -alkyl-NR23+, -aryl-NR23+, -alkyl-CO2, -aryl-CO2, -amino acid-NH3+, -phosphorylated amino acid-NH3+, polyethylene glycol, dextran, H, alkyl,

OG Complex Work Unit Drawing
 or aryl; and
at least one biologically inactive carrier.