US 7,320,963 B2
Methods and compositions for delivery of pharmaceutical agents
Kesavan Esuvaranathan, Singapore (Singapore); Ratha Mahendran, Singapore (Singapore); and Carmel Lawrencia, Singapore (Singapore)
Assigned to Genecure Pte Ltd, Singapore (Singapore)
Filed on Mar. 01, 2002, as Appl. No. 10/86,973.
Application 10/086973 is a continuation of application No. PCT/SG00/00130, filed on Sep. 01, 2000.
Claims priority of application No. PQ2593 (AU), filed on Sep. 01, 1999.
Prior Publication US 2002/0146830 A1, Oct. 10, 2002
Int. Cl. A61K 31/715 (2006.01); A61K 48/00 (2006.01); G01N 31/00 (2006.01); G01N 33/00 (2006.01)
U.S. Cl. 514—44  [424/93.2; 514/58; 436/15; 436/71] 58 Claims
 
1. A transfection composition comprising:
(i) a polynucleotide;
(ii) a cationic lipid, a cationic polymer or a dendrimer, or combinations thereof; and
(iii) a solubilized cholesterol preparation, wherein the solubilized cholesterol preparation comprises cholesterol solubilized with a cyclodextrin.