US 7,320,963 B2 | ||
Methods and compositions for delivery of pharmaceutical agents | ||
Kesavan Esuvaranathan, Singapore (Singapore); Ratha Mahendran, Singapore (Singapore); and Carmel Lawrencia, Singapore (Singapore) | ||
Assigned to Genecure Pte Ltd, Singapore (Singapore) | ||
Filed on Mar. 01, 2002, as Appl. No. 10/86,973. | ||
Application 10/086973 is a continuation of application No. PCT/SG00/00130, filed on Sep. 01, 2000. | ||
Claims priority of application No. PQ2593 (AU), filed on Sep. 01, 1999. | ||
Prior Publication US 2002/0146830 A1, Oct. 10, 2002 | ||
Int. Cl. A61K 31/715 (2006.01); A61K 48/00 (2006.01); G01N 31/00 (2006.01); G01N 33/00 (2006.01) |
U.S. Cl. 514—44 [424/93.2; 514/58; 436/15; 436/71] | 58 Claims |
1. A transfection composition comprising:
(i) a polynucleotide;
(ii) a cationic lipid, a cationic polymer or a dendrimer, or combinations thereof; and
(iii) a solubilized cholesterol preparation, wherein the solubilized cholesterol preparation comprises cholesterol solubilized
with a cyclodextrin.
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