US 7,320,789 B2
Antibody inhibitors of GDF-8 and uses thereof
Jane Aghajanian, deceased, late of Belgrade, Me. (US), by William J. Dunham, legal representative, ; Neil M. Wolfman, Dover, Mass. (US); Denise O'Hara, Reading, Mass. (US); Monique V. Davies, Harpswell, Mass. (US); Geertruida M. Veldman, Sudbury, Mass. (US); Kristie Grove Bridges, Maynard, Mass. (US); and Lisa-Anne Whittemore, East Walpole, Mass. (US)
Assigned to Wyeth, Madison, N.J. (US)
Filed on Sep. 25, 2002, as Appl. No. 10/253,532.
Claims priority of provisional application 60/324528, filed on Sep. 26, 2001.
Prior Publication US 2003/0138422 A1, Jul. 24, 2003
Int. Cl. A61K 39/00 (2006.01); C07K 16/00 (2006.01); C12N 5/16 (2006.01)
U.S. Cl. 424—130.1  [424/133.1; 424/135.1; 424/141.1; 435/326; 530/387.1; 530/388.1] 35 Claims
 
1. An isolated antibody that specifically binds to amino acids 1–50 of the polypeptide of SEQ ID NO:15, wherein the antibody reduces GDF-8 activity associated with negative regulation of muscle mass.