US 7,321,043 B2
Processes for the preparation of 2-aminomethylpyridines and the 2-cyanopyridines used in their preparation
Norman Dann, Cambridgeshire (United Kingdom); Peter Dominic Riordan, Bristol (United Kingdom); Mehul Rasikchandra Amin, Suffolk (United Kingdom); and Michael Mellor, Suffolk (United Kingdom)
Assigned to Bayer Cropscience S.A., (France)
Filed on Jul. 08, 2005, as Appl. No. 11/177,118.
Application 11/177118 is a continuation of application No. 10/362728, granted, now 6,921,828, previously published as PCT/EP01/10984, filed on Aug. 21, 2001.
Claims priority of application No. 0021066.6 (GB), filed on Aug. 25, 2000; application No. 0025616.4 (GB), filed on Oct. 19, 2000; and application No. 01420128 (EP), filed on Jun. 07, 2001.
Prior Publication US 2005/0250947 A1, Nov. 10, 2005
Int. Cl. C07D 213/57 (2006.01)
U.S. Cl. 546—288  [546/286] 8 Claims
 
1. A process for the preparation of a compound of the formula (II):

OG Complex Work Unit Drawing
or a salt thereof, wherein X is halogen; each Y, which may be the same or different, is halogen, haloalkyl, alkoxycarbonyl or alkylsulphonyl, and n is 0 to 3;which process comprises treating a compound of the formula (III):

OG Complex Work Unit Drawing
with a cyanide source and a catalyst selected from the group consisting of a tetraalkyl ammonium salt and a tetraalkyl phosphonium salt in an aqueous solvent or without solvent,wherein:X is halogen; each Y, which may be the same or different, is halogen, haloalkyl, alkoxycarbonyl or alkylsulphonyl: and n is 0 to 3; and wherein the cyanide source is hydrogen cyanide, an alkali metal cyanide, an alkaline earth metal cyanide or an optionally substituted ammonium cyanide.