US 7,320,728 B2
Rod-shaped apatite crystals having a specific length-to-width ratio
Ralf Noerenberg, Ingelheim (Germany); Hans-Josef Sterzel, Dannstadt-Schauernheim (Germany); and Volker Koch, Battenberg (Germany)
Assigned to BASF Aktiengesellschaft, Ludwigshafen (Germany)
Filed on Nov. 07, 2006, as Appl. No. 11/557,291.
Application 11/557291 is a division of application No. 11/169681, filed on Jun. 30, 2005, granted, now 7,153,482.
Application 11/169681 is a continuation of application No. 10/480809, abandoned, previously published as PCT/EP02/06867, filed on Jun. 20, 2002.
Prior Publication US 2007/0065355 A1, Mar. 22, 2007
Int. Cl. A61K 6/033 (2006.01); C01B 25/10 (2006.01); C01B 25/12 (2006.01); C09K 3/00 (2006.01)
U.S. Cl. 106—35  [501/1; 423/301; 423/308; 424/57; 424/602] 16 Claims
 
1. A method of using a mixture comprising rod-shaped apatite crystals, the method comprising applying, on at least one selected from the group consisting of teeth and bones, a mixture comprising rod-shaped apatite crystals of the formula Ca5(PO4)3(OH)xFy, where
a) the length-to-breadth ratio of substantially all of the rod-shaped apatite crystals is≧5,
b) x+y=1, and
c) the breadth of the rod-shaped apatite crystals is in a range of 0.01 to 0.02 μm and the length of the rod-shaped apatite crystals is in a range of 0.1 to 0.2 μm.