US 7,321,044 B2 | ||
Synthesis of oxygen-substituted benzocycloheptenes as valuable intermediate products for the production of tissue-selective estrogens | ||
Johannes Platzek, Berlin (Germany); Wolfgang Beckmann, Berlin (Germany); Jens Geisler, Berlin (Germany); Holger Kirstein, Berlin (Germany); Ulrich Niedballa, Berlin (Germany); Eckhard Ottow, Berlin (Germany); Sigmar Radau, Berlin (Germany); Claudia Schulz, Berlin (Germany); and Thomas Wessa, Berlin (Germany) | ||
Assigned to Schering Aktiengesellschaft, Berlin (Germany) | ||
Filed on Oct. 15, 2002, as Appl. No. 10/270,080. | ||
Claims priority of provisional application 60/330681, filed on Oct. 29, 2001. | ||
Claims priority of application No. 101 51 095 (DE), filed on Oct. 12, 2001. | ||
Prior Publication US 2003/0162974 A1, Aug. 28, 2003 | ||
Int. Cl. C07D 211/70 (2006.01); C07D 233/56 (2006.01) |
U.S. Cl. 546—339 [546/341; 548/346.1; 549/80; 568/319; 568/633; 562/456] | 34 Claims |
1. A process for the production of compounds of formula I
![]() L is a C2–C10 alkylene chain, which can be unbranched or branched,
X is Cl or Br,
Ar is an aromatic or heteroaromatic radical, which optionally can be substituted with up to 3 substituents, said process comprising:
cleaving the aromatic methyl ether in a compound of formula II
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