US 7,321,027 B2
Small technetium-99m and rhenium labeled agents and methods for imaging tumors
Ashfaq Mahmood, Newton Center, Mass. (US); Matthias Friebe, Berlin (Germany); Cristina Bolzati, Ferrara (Italy); Alun G. Jones, Newton Center, Mass. (US); and Alan Davison, North Falmouth, Mass. (US)
Assigned to President and Fellows of Harvard College, Cambridge, Mass. (US); and Massachusetts Institute of Technology, Cambridge, Mass. (US)
Filed on Oct. 23, 2002, as Appl. No. 10/279,214.
Application 10/279214 is a continuation of application No. PCT/US01/13550, filed on Apr. 27, 2001.
Claims priority of provisional application 60/200633, filed on Apr. 28, 2000.
Prior Publication US 2004/0097735 A1, May 20, 2004
Int. Cl. C07F 13/00 (2006.01)
U.S. Cl. 534—14  [534/10; 534/15; 534/16; 424/1.11; 424/1.65] 19 Claims
 
1. A compound represented by the formula:

OG Complex Work Unit Drawing
wherein:
R1 and R2 each are independently selected from lower alkyl group having 1 to about 4 carbon atoms; or
—NR1R2 taken in combination is a heterocyclic ring according to the formula:

OG Complex Work Unit Drawing
where A is CH2, NRD, O or S;
RD is chosen from the group consisting of hydrogen, lower alkyl group having from 1 to about 4 carbon atoms, aralkyl groups having from 7 to about 18 carbon atoms, aryl groups having 6 to about 18 carbon atoms, alkyl ester groups having about 2 to about 8 carbon atoms, and aryl ester groups having about 7 to about 18 carbon atoms;
X is a —(CH2)q group; and
q is an integer selected from 1 to 6.