US 7,321,034 B2
Process for the physical depolymerization of glycosaminogylcanes and products obtained thereform
Luigi De Ambrosi, Santhia (Italy); Nicola Iannaccone, Pisa (Italy); Sergio Gonella, Santhia (Italy); Elena Vismara, Milan (Italy); Solitario Nesti, Baronto (Italy); and Giangiaocomo Torri, Milan (Italy)
Assigned to Laboratori Derivati Organici S.p.A., Trino Vercelli (Italy)
Appl. No. 10/518,980
PCT Filed Jun. 18, 2003, PCT No. PCT/EP03/06446
§ 371(c)(1), (2), (4) Date May 31, 2005,
PCT Pub. No. WO04/000886, PCT Pub. Date Dec. 31, 2003.
Claims priority of application No. MI2002A1372 (IT), filed on Jun. 21, 2002.
Prior Publication US 2005/0240013 A1, Oct. 27, 2005
Int. Cl. C08B 37/10 (2006.01)
U.S. Cl. 536—124  [536/21; 536/53; 201/157.63] 6 Claims
 
1. A process for the depolymerization of glycosaminoglycanes consisting essentially of:
exposing an aqueous solution to electron beam radiation, said solution consisting essentially of:
i) water;
ii) a glycosaminoglycane; and
iii) optionally, an organic compound selected from the group consisting of Formula I, Formula II, and Formula III:

OG Complex Work Unit Drawing
wherein each R is independently selected from the group consisting of H, OH, CHO, C1-C6 alkyl and acyl, optionally substituted by oxygen atoms; two R groups optionally join together to form a ring, and wherein the concentration of the organic compound is from 0.1% to 5%.