US 7,320,803 B2
Crystalline choline ascorbate
Ludwig Völkel, Limburgerhof (Germany); Alfred Oftring, Bad Dürkheim (Germany); Oliver Hasselwander, Landau (Germany); Ulrike Sindel, München (Germany); and Klaus Krämer, Landau (Germany)
Assigned to BASF Aktiengesellschaft, Ludwigshafen (Germany)
Filed on Feb. 19, 2002, as Appl. No. 10/76,514.
Claims priority of application No. 101 09 073 (DE), filed on Feb. 23, 2001.
Prior Publication US 2002/0161039 A1, Oct. 31, 2002
Int. Cl. C07C 213/00 (2006.01)
U.S. Cl. 424—489  [424/442; 514/474; 564/293] 3 Claims
OG exemplary drawing
 
1. A process for preparing choline ascorbate, wherein the choline ascorbate is obtained in form of anhydrous crystals having diffraction lines at d=3.80 Å and 4.55 Å, and having diffraction lines which are most intense in a range between 3.40 and 4.70 Å, in a 2 Θ X-ray powder diffractogram and having a melting point from 123.5 to 124.4° C. or in the range from 123.5 to 124.4° C., which process comprises
a) providing a mixture of ascorbic acid, trimethylamine and a solvent,
b) adding to the mixture gaseous ethylene oxide, and
c) crystallizing the choline ascorbate,
wherein stages (a) and (b) are carried out at a temperature of from 0° C. to 5° C., andthe solvent is a water miscible organic solvent or is a mixture of said organic solvent and water.