US 7,320,973 B2
Dihydrodiaryloxazepine derivative and pharmaceutical composition containing the same
Katsutoshi Sakata, Kawasaki (Japan); Takashi Tsuji, Kawasaki (Japan); Munetaka Tokumasu, Kawasaki (Japan); Kazuyoshi Takahashi, Kawasaki (Japan); Shigeo Hirasawa, Kawasaki (Japan); and Junko Ezaki, Kawasaki (Japan)
Assigned to Ajinomoto Co., Inc., Tokyo (Japan)
Filed on Dec. 01, 2003, as Appl. No. 10/724,179.
Application 10/724179 is a continuation of application No. PCT/JP02/05193, filed on May 29, 2002.
Claims priority of application No. 2001-161988 (JP), filed on May 30, 2001.
Prior Publication US 2004/0110742 A1, Jun. 10, 2004
Int. Cl. A61P 1/00 (2006.01); A61K 31/553 (2006.01); C07D 267/18 (2006.01); C07D 413/00 (2006.01)
U.S. Cl. 514—211.02  [514/211.1; 514/211.12; 540/548; 540/550] 26 Claims
 
1. A 5,11-Dihydrodiaryl[b,e][1,4]oxazepine represented by the following formula [I], a stereoisomer thereof, a pharmacologically acceptable salt thereof, or a hydrate thereof:

OG Complex Work Unit Drawing
wherein rings G, J and K each represent benzene ring or a nitrogen-containing aromatic ring; each of R1, R2, R3, R4, R5, R6, R7, and R8 may be the same or different from one another and they each represent a halogen atom or hydrogen atom, each of R9, R10, R11, R12, and R13 may be the same or different from one another and they each represent a hydrogen atom, a halogen atom, cyano group, hydroxyl group, a lower alkyl group, a lower alkoxyl group, amino group, a lower alkylamino group, a lower acylated amino group, a lower acylated lower alkylamino group, a lower dialkylamino group or a cycloalkylamino group, or R9 and R10 or R10 and R11 together form —O(CH2)n′O— group wherein n′ is 1, 2 or 3; A represents CH2, CHOH, CO or O; B represents CH2, CHOH or CO; or A-B represents CH═CH, D represents CH2, CH2—CH2 or CH2—CH2—CH2 or B-D represents CH2; X and z are bonded together to form CH2—CH2 or CH2—CH2—CH2 and, in this case, Y represents a hydrogen atom; or Y and z are bonded together to form CH2—CH2—CH2 or CH2—CH2—CH2—CH2 and, in this case, X represents a hydrogen atom; and when X and z, and Y and z are not bonded together, X and Y each represent a hydrogen atom and z represents a lower alkyl group;
provided that when any of R9, R10, R11, R12, and R13 represents a cyclic amino group of the following formula [E], each of R1, R2, R3, R4, R5, R6, R7, and R8 may be a halogen atom or hydrogen atom but when none of R9, R10, R11, R12, and R13 is a cyclic amino group of formula [E], one or two of R1, R2, R3, R4, R5, R6, R7, and R8 represent a halogen atom and the others represent a hydrogen atom:

OG Complex Work Unit Drawing
wherein n and m each represent 1 or 2, and W represents carbon atom, or nitrogen which may be substituted with a lower alkyl group, or oxygen, or sulfur atom.