US 7,320,872 B2
Ependymal neural stem cells and method for their isolation
Ann Marie Janson, Stockholm (Sweden); Jonas Frisen, Stockholm (Sweden); Clas Johansson, Stockholm (Sweden); Stefan Momma, Spinga (Sweden); Diana Clarke, Cambridge, Mass. (US); Ming Zhao, Solna (Sweden); Urban Lendahl, Stockholm (Sweden); and Kioumars Delfani, Solna (Sweden)
Assigned to NeuroNova AB, Stockholm (Sweden)
Filed on Jun. 27, 2002, as Appl. No. 10/183,728.
Application 10/183728 is a continuation of application No. 09/719001, abandoned, previously published as PCT/SE99/01157, filed on Jun. 24, 1999.
Claims priority of application No. 9802264 (SE), filed on Jun. 25, 1998.
Prior Publication US 2003/0092176 A1, May 15, 2003
Int. Cl. G01N 33/567 (2006.01)
U.S. Cl. 435—7.21  [435/368; 435/381] 26 Claims
 
1. An isolated ependymal neural CNS stem cell from a mammal, wherein said stem cell expresses Notch 1 and one or more other cell surface proteins, wherein the cell surface protein is selected from the group consisting of Notch 2, Notch 3, CAR, and CFTR.