US 7,320,803 B2 | ||
Crystalline choline ascorbate | ||
Ludwig Völkel, Limburgerhof (Germany); Alfred Oftring, Bad Dürkheim (Germany); Oliver Hasselwander, Landau (Germany); Ulrike Sindel, München (Germany); and Klaus Krämer, Landau (Germany) | ||
Assigned to BASF Aktiengesellschaft, Ludwigshafen (Germany) | ||
Filed on Feb. 19, 2002, as Appl. No. 10/76,514. | ||
Claims priority of application No. 101 09 073 (DE), filed on Feb. 23, 2001. | ||
Prior Publication US 2002/0161039 A1, Oct. 31, 2002 | ||
Int. Cl. C07C 213/00 (2006.01) |
U.S. Cl. 424—489 [424/442; 514/474; 564/293] | 3 Claims |
1. A process for preparing choline ascorbate, wherein the choline ascorbate is obtained in form of anhydrous crystals having
diffraction lines at d=3.80 Å and 4.55 Å, and having diffraction lines which are most intense in a range between 3.40 and
4.70 Å, in a 2 Θ X-ray powder diffractogram and having a melting point from 123.5 to 124.4° C. or in the range from 123.5
to 124.4° C., which process comprises
a) providing a mixture of ascorbic acid, trimethylamine and a solvent,
b) adding to the mixture gaseous ethylene oxide, and
c) crystallizing the choline ascorbate, wherein stages (a) and (b) are carried out at a temperature of from 0° C. to 5° C., andthe solvent is a water miscible organic solvent or is a mixture of said organic solvent and water.
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