US 7,320,728 B2 | ||
Rod-shaped apatite crystals having a specific length-to-width ratio | ||
Ralf Noerenberg, Ingelheim (Germany); Hans-Josef Sterzel, Dannstadt-Schauernheim (Germany); and Volker Koch, Battenberg (Germany) | ||
Assigned to BASF Aktiengesellschaft, Ludwigshafen (Germany) | ||
Filed on Nov. 07, 2006, as Appl. No. 11/557,291. | ||
Application 11/557291 is a division of application No. 11/169681, filed on Jun. 30, 2005, granted, now 7,153,482. | ||
Application 11/169681 is a continuation of application No. 10/480809, abandoned, previously published as PCT/EP02/06867, filed on Jun. 20, 2002. | ||
Prior Publication US 2007/0065355 A1, Mar. 22, 2007 | ||
Int. Cl. A61K 6/033 (2006.01); C01B 25/10 (2006.01); C01B 25/12 (2006.01); C09K 3/00 (2006.01) |
U.S. Cl. 106—35 [501/1; 423/301; 423/308; 424/57; 424/602] | 16 Claims |
1. A method of using a mixture comprising rod-shaped apatite crystals, the method comprising applying, on at least one selected
from the group consisting of teeth and bones, a mixture comprising rod-shaped apatite crystals of the formula Ca5(PO4)3(OH)xFy, where
a) the length-to-breadth ratio of substantially all of the rod-shaped apatite crystals is≧5,
b) x+y=1, and
c) the breadth of the rod-shaped apatite crystals is in a range of 0.01 to 0.02 μm and the length of the rod-shaped apatite
crystals is in a range of 0.1 to 0.2 μm.
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