US 7,321,040 B2 | ||
Triazolo-pyridines as anti-inflammatory compounds | ||
John Frederick Braganza, San Diego, Calif. (US); Michael Anthony Letavic, San Diego, Calif. (US); and Kim F. McClure, Mystic, Conn. (US) | ||
Assigned to Pfizer Inc., New York, N.Y. (US) | ||
Filed on Feb. 11, 2004, as Appl. No. 10/776,953. | ||
Claims priority of provisional application 60/447787, filed on Feb. 14, 2003. | ||
Prior Publication US 2005/0075365 A1, Apr. 07, 2005 | ||
Int. Cl. C07D 471/02 (2006.01); C07D 491/02 (2006.01); C07D 498/02 (2006.01); C07D 513/02 (2006.01); C07D 515/02 (2006.01) |
U.S. Cl. 546—119 | 37 Claims |
1. A compound of the formula
![]() wherein the molecular weight of the compound of formula I is less than 1000 AMU;
X is >CH2>NH, sulfur, >S═O, >SO2 or oxygen;
R1 is selected from the group consisting of hydrogen, (C1-C6)alkyl;
R2 is selected from the group consisting of hydrogen, (C1-C6)alkyl;
s is an integer from 0-4;
R3 is R4, R5—(NR6)—, R5—S—, R5—(S═O)—, R5—(SO2)—, R5—SO2—NR6—, R5—(NR6)—SO2—, R5—O—, R5—(C═O)—, R5—(NR6)—(C═O)—, R5—(C═O)—NR6—, R5—O—(C═O)—, R5—(C═O)—O—, R5—CR7═CR8— or R5—C≡C—;
such that the molecular weight of R3 is less than 500 AMU;
R4, R5 and R6 are each selected from the group consisting of hydrogen, (C1-C6)alkyl;
wherein the molecular weight of the compound of formula I is less than 1000 AMU;
or a pharmaceutically acceptable salt thereof.
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