US 7,320,996 B2
Indolinone protein kinase inhibitors and cyclooxygenase inhibitors for use in combination therapy for the treatment of cancer
Jaime Masferrer, Ballwin, Mo. (US); Parul Doshi, Wildwood, Mo. (US); and Julie Cherrington, San Francisco, Calif. (US)
Assigned to Sugen, Inc, South San Francisco, Calif. (US); and Pharmacia Corporation, St. Louis, Mo. (US)
Filed on Aug. 15, 2002, as Appl. No. 10/218,910.
Claims priority of provisional application 60/312413, filed on Aug. 15, 2001.
Prior Publication US 2003/0216410 A1, Nov. 20, 2003
Int. Cl. A61K 31/40 (2006.01); A61K 31/415 (2006.01)
U.S. Cl. 514—414  [514/403] 2 Claims
 
1. A method for the treatment of breast cancer comprising administering to a mammal in need of such treatment a therapeutically effective amount of a) a protein kinase inhibitor having the formula

OG Complex Work Unit Drawing
or a pharmaceutically acceptable salt thereof and b) a cyclooxygenase-2 selective inhibitor having the formula

OG Complex Work Unit Drawing
or a pharmaceutically acceptable salt thereof.