US 7,320,806 B2
Compositions and methods for treating NIDDM and other conditions and disorders associated with AMPK regulation
Dusan Miljkovic, San Diego, Calif. (US); and Zbigniew Pietrzkowski, San Diego, Calif. (US)
Assigned to VDF Futureceuticals, Inc., Momence, Ill. (US)
Appl. No. 10/526,837
PCT Filed Aug. 29, 2003, PCT No. PCT/US03/27012
§ 371(c)(1), (2), (4) Date Oct. 26, 2005,
PCT Pub. No. WO2004/021980, PCT Pub. Date Mar. 18, 2004.
Prior Publication US 2006/0134240 A1, Jun. 22, 2006
Int. Cl. A61K 36/8998 (2006.01)
U.S. Cl. 424—750 12 Claims
 
1. A method for activating adenosine 5′-monophosphate-activated protein kinase (AMPK) in a patient in need thereof, wherein the method comprises malting barley, grinding the malted barley, and extracting the malted barley with a solvent to obtain a malted barley extract; fractionating the malted barley extract by ion exchange chromatography to form fractions thereof; pooling the desired fractions and optionally removing protein from the pooled fractions by molecular sieving chromatography to prepare a low-molecular weight composition from a formed fraction; administering to said patient the low molecular weight composition in therapeutically effective amount that activates AMPK.