1. A 5,11-Dihydrodiaryl[b,e][1,4]oxazepine represented by the following formula [I], a stereoisomer thereof, a pharmacologically
acceptable salt thereof, or a hydrate thereof:
wherein rings G, J and K each represent benzene ring or a nitrogen-containing aromatic ring; each of R1, R2, R3, R4, R5, R6,
R7, and R8 may be the same or different from one another and they each represent a halogen atom or hydrogen atom, each of
R9, R10, R11, R12, and R13 may be the same or different from one another and they each represent a hydrogen atom, a halogen
atom, cyano group, hydroxyl group, a lower alkyl group, a lower alkoxyl group, amino group, a lower alkylamino group, a lower
acylated amino group, a lower acylated lower alkylamino group, a lower dialkylamino group or a cycloalkylamino group, or R9
and R10 or R10 and R11 together form —O(CH2)n′O— group wherein n′ is 1, 2 or 3; A represents CH2, CHOH, CO or O; B represents CH2, CHOH or CO; or A-B represents CH═CH, D represents CH2, CH2—CH2 or CH2—CH2—CH2 or B-D represents CH2; X and z are bonded together to form CH2—CH2 or CH2—CH2—CH2 and, in this case, Y represents a hydrogen atom; or Y and z are bonded together to form CH2—CH2—CH2 or CH2—CH2—CH2—CH2 and, in this case, X represents a hydrogen atom; and when X and z, and Y and z are not bonded together, X and Y each represent
a hydrogen atom and z represents a lower alkyl group;
provided that when any of R9, R10, R11, R12, and R13 represents a cyclic amino group of the following formula [E], each of
R1, R2, R3, R4, R5, R6, R7, and R8 may be a halogen atom or hydrogen atom but when none of R9, R10, R11, R12, and R13 is a
cyclic amino group of formula [E], one or two of R1, R2, R3, R4, R5, R6, R7, and R8 represent a halogen atom and the others
represent a hydrogen atom:
wherein n and m each represent 1 or 2, and W represents carbon atom, or nitrogen which may be substituted with a lower alkyl
group, or oxygen, or sulfur atom.
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