US 7,321,039 B2
Industrial process for preparing tropenol
Rolf Banholzer, Stuttgart (Germany); Gisela Bodenbach, Niederburg (Germany); Andreas Mathes, Ockenheim (Germany); Helmut Meissner, Ingelheim (Germany); and Peter Specht, Ober-Hilbersheim (Germany)
Assigned to Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim (Germany)
Filed on Jan. 18, 2005, as Appl. No. 11/38,935.
Application 11/038935 is a continuation of application No. 10/764922, filed on Jan. 26, 2004, granted, now 6,891,042.
Application 10/764922 is a continuation of application No. 10/448493, filed on May 29, 2003, granted, now 6,747,153.
Claims priority of provisional application 60/407121, filed on Aug. 30, 2002.
Claims priority of application No. 102 24 091 (DE), filed on May 31, 2002.
Prior Publication US 2005/0124813 A1, Jun. 09, 2005
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 491/00 (2006.01)
U.S. Cl. 546—90  [546/127; 546/131] 1 Claim
 
1. A process for preparing compound of formula (IV)

OG Complex Work Unit Drawing
wherein
R denotes a group selected from C1-C4-alkyl, C2-C6-alkenyl and C1-C4-alkylene-phenyl, each of which may be subtituted by hydroxy or C1-C4-alkoxy, and
R″ denotes a group selected from C1-C4-alkyl and C1-C4-alkylene-phenyl comprising reacting a compound of formula (II)

OG Complex Work Unit Drawing
wherein
R denotes a group selected from C1-C4-alkyl, C2-C6-alkenyl and C1-C4-alkylcne-phenyl, each of which may be substituted by hydrixy or C1-C4-alkoxy, optionally in the form of an acid addition salt thereof or a hydrate thereof, in a suitable solvent with a formamide-acetal of formula (III)

OG Complex Work Unit Drawing
wherein
R′ denotes C1-C4-alkyl and R″ denotes a group selected from C1-C4-alkyl and C1-C4-alkyle-phenyl.