US 7,320,873 B2 | ||
Use of antibodies against specific MHC-peptide complexes | ||
Petrus Gerardus Antonius Steenbakkers, Wethouder Donkerstraat (Netherlands) | ||
Assigned to N.V. Organon, Oss (Netherlands) | ||
Appl. No. 10/344,872 PCT Filed Aug. 08, 2001, PCT No. PCT/EP01/09136 § 371(c)(1), (2), (4) Date Feb. 14, 2003, PCT Pub. No. WO02/14870, PCT Pub. Date Feb. 21, 2002. |
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Prior Publication US 2004/0137514 A1, Jul. 15, 2004 | ||
Int. Cl. G01N 33/564 (2006.01); G01N 33/563 (2006.01); C07K 16/28 (2006.01) |
U.S. Cl. 435—7.21 [530/388.2; 530/388.22; 530/389.1; 530/866; 530/868] | 14 Claims |
1. A method for diagnosing rheumatoid arthritis, comprising detecting the presence of a rheumatoid arthritis specific MHC-peptide complex in a patient with antibodies, or antigen binding domains thereof, which specifically bind to a MHC-HC-gp39-derived peptide complex and do not specifically bind to the HC-gp39-derived peptide or the MHC alone. |