US 7,321,039 B2 | ||
Industrial process for preparing tropenol | ||
Rolf Banholzer, Stuttgart (Germany); Gisela Bodenbach, Niederburg (Germany); Andreas Mathes, Ockenheim (Germany); Helmut Meissner, Ingelheim (Germany); and Peter Specht, Ober-Hilbersheim (Germany) | ||
Assigned to Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim (Germany) | ||
Filed on Jan. 18, 2005, as Appl. No. 11/38,935. | ||
Application 11/038935 is a continuation of application No. 10/764922, filed on Jan. 26, 2004, granted, now 6,891,042. | ||
Application 10/764922 is a continuation of application No. 10/448493, filed on May 29, 2003, granted, now 6,747,153. | ||
Claims priority of provisional application 60/407121, filed on Aug. 30, 2002. | ||
Claims priority of application No. 102 24 091 (DE), filed on May 31, 2002. | ||
Prior Publication US 2005/0124813 A1, Jun. 09, 2005 | ||
This patent is subject to a terminal disclaimer. | ||
Int. Cl. C07D 491/00 (2006.01) |
U.S. Cl. 546—90 [546/127; 546/131] | 1 Claim |
1. A process for preparing compound of formula (IV)
![]() R denotes a group selected from C1-C4-alkyl, C2-C6-alkenyl and C1-C4-alkylene-phenyl, each of which may be subtituted by hydroxy or C1-C4-alkoxy, and
R″ denotes a group selected from C1-C4-alkyl and C1-C4-alkylene-phenyl comprising reacting a compound of formula (II)
![]() wherein
R denotes a group selected from C1-C4-alkyl, C2-C6-alkenyl and C1-C4-alkylcne-phenyl, each of which may be substituted by hydrixy or C1-C4-alkoxy, optionally in the form of an acid addition salt thereof or a hydrate thereof, in a suitable solvent with a formamide-acetal
of formula (III)
![]() wherein
R′ denotes C1-C4-alkyl and R″ denotes a group selected from C1-C4-alkyl and C1-C4-alkyle-phenyl.
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