US 7,321,064 B1 | ||
Preparation of amides of retinoic acid via mixed anhydride and mixed carbonate intermediates | ||
John E. Cabaj, Sheboygan, Wis. (US); and Jeff J. Hutchison, Sheboygan, Wis. (US) | ||
Assigned to Cedarburg Pharmaceuticals, Inc., Grafton, Wis. (US) | ||
Filed on Mar. 08, 2007, as Appl. No. 11/715,571. | ||
Int. Cl. C07C 231/00 (2006.01) |
U.S. Cl. 564—133 | 19 Claims |
1. A process for preparing an amide of retinoic acid, the process comprising:
(a) reacting a retinoic acid having the formula:
![]() ![]() ![]() ![]() (b) reacting the intermediate with 4-aminophenol to produce an amide of retinoic acid having the formula:
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