US 12,169,194 B2
And methods for measuring analytes using nanofabricated device
Steven Henck, Mountain View, CA (US)
Assigned to Roche Sequencing Solutions, Inc., Pleasanton, CA (US)
Filed by Roche Sequencing Solutions, Inc., Pleasanton, CA (US)
Filed on Aug. 3, 2023, as Appl. No. 18/230,113.
Application 17/839,085 is a division of application No. 15/851,608, filed on Dec. 21, 2017, granted, now 11,391,719, issued on Jul. 19, 2022.
Application 18/230,113 is a continuation of application No. 17/839,085, filed on Jun. 13, 2022, granted, now 11,754,549.
Application 15/851,608 is a continuation of application No. PCT/EP2016/065155, filed on Jun. 29, 2016.
Claims priority of provisional application 62/187,161, filed on Jun. 30, 2015.
Prior Publication US 2024/0060956 A1, Feb. 22, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 33/487 (2006.01); C12Q 1/6869 (2018.01); G01N 27/447 (2006.01)
CPC G01N 33/48721 (2013.01) [C12Q 1/6869 (2013.01); G01N 27/44791 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A system for sequencing a plurality of linear biomolecules using quantum tunneling, the system comprising:
a plurality of devices for simultaneously sequencing the plurality of linear biomolecules, wherein each of the plurality of devices comprises:
a substrate having a top surface;
a first electrode disposed on and in contact with a first portion of the top surface of the substrate;
a first dielectric layer disposed on and in contact with a second portion of the top surface of the substrate, wherein a top surface of the first dielectric layer and a top surface of the first electrode are substantially coplanar;
a second electrode, wherein:
a first portion of the second electrode is disposed on and in contact with the top surface of the first dielectric layer; and
a second portion of the second electrode is suspended over the first electrode thereby extending over the first electrode to span from a first end of the first electrode to an opposite end of the first electrode in a continuous manner; and
a gap defined by the top surface of the first electrode, a bottom surface of the second electrode, and the top surface of the first dielectric layer.