CPC B30B 11/005 (2013.01) [B30B 11/34 (2013.01); G01N 1/04 (2013.01)] | 8 Claims |
1. A method for sampling both layers of a bi-layer tablet, the method comprising:
forming a first layer of a first pharmaceutical powder of the bi-layer tablet in a tablet press machine;
performing weight compensation for forming a second layer of a second pharmaceutical powder of the bi-layer tablet based at least on the formed first layer;
performing height compensation for forming the second layer of the second pharmaceutical powder of the bi-layer tablet based at least on the formed first layer,
wherein the step of performing height compensation comprises:
(i) determining a cylindrical height for the weight compensated second layer of the bi-layer tablet, wherein the step of determining the cylindrical height of the second layer comprises deducting sum of the cylindrical height of the formed first layer and a second layer height compensation factor, from an actual cylindrical height of the both the first and second layers in the die; and
(ii) displacing a compression means of the tablet press machine by a distance based on the determined cylindrical height for the weight compensated second layer to form a hardened second layer in the die of the tablet press machine; and
forming the second layer of the bi-layer tablet based on the performed height compensation and weight compensation, in the tablet press machine, for individually sampling both the first and second layers of the bi-layer tablet.
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