CPC A61K 31/426 (2013.01) [C12N 15/113 (2013.01); C12N 2310/11 (2013.01); C12N 2310/14 (2013.01); C12N 2310/141 (2013.01)] | 15 Claims |
1. A method of inhibiting T Follicular Helper (TFH) cell-mediated differentiation and/or activation in a subject, said method comprising:
administering to a subject in need of treatment for an autoimmune disorder a eukaryotic translation initiation factor 4E (eIF4E) inhibitor to inhibit TFH cell-mediated differentiation and/or activation in the subject, wherein the autoimmune disorder is selected from the group consisting of multiple sclerosis (MS), rheumatoid arthritis, asthma, allergies and food allergies, anaphylactic responses, Jorgen syndrome, autoimmune encephalitis (EAE), lupus nephritis, Type I diabetes, juvenile dermatomyositis, autoimmune myasthenia gravis, autoimmune thyroid disease, atherosclerosis, and graft versus host disease.
|