CPC A61K 48/0066 (2013.01) [A61P 27/00 (2018.01); C12N 9/22 (2013.01); C12N 15/11 (2013.01); C12N 15/113 (2013.01); C12N 15/1137 (2013.01); C12Y 301/00 (2013.01)] | 6 Claims |
1. An isolated guide RNA (gRNA) that targets a mutant human guanylate cyclase 2D (GUCY2D) allele, wherein the gRNA comprises a CRISPR RNA (crRNA) consisting of the nucleic acid sequence of SEQ ID NO: 237, 238, 241, 242, 247, 248, 293, 294, 307, 413, 414, 417, 418, or 3011.
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