CPC C12N 9/1252 (2013.01) [C12N 9/2497 (2013.01); C12N 9/99 (2013.01); C12N 15/113 (2013.01); C12N 15/115 (2013.01); C12Q 1/686 (2013.01); C12N 2310/16 (2013.01); C12N 2310/531 (2013.01); C12Y 207/07007 (2013.01)] | 12 Claims |
1. An oligonucleotide aptamer, comprising a DNA polymerase-binding nucleic acid sequence that is capable of forming a hairpin structure having a stem sequence portion and a loop sequence portion, wherein the loop sequence portion comprises a nucleotide sequence 5′-TTCTTAGCGTTT-3′ (SEQ ID NO:23) wherein one or more thymidine nucleotides at positions 1, 2, 10, 11 and 12 of the SEQ ID NO:23 sequence are substituted by one or more deoxyuridine nucleotides modifiable by a uracil-DNA glycosylase enzymatic activity.
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