US 12,168,134 B2
System and method for locating an implantation site in the brain
Nuri F. Ince, Humble, TX (US); Musa Ozturk, Houston, TX (US); and Ashwin Viswanathan, Houston, TX (US)
Assigned to UNIVERSITY OF HOUSTON SYSTEM, Houston, TX (US)
Filed by University of Houston System, Houston, TX (US)
Filed on Aug. 12, 2021, as Appl. No. 17/400,306.
Claims priority of provisional application 63/068,186, filed on Aug. 20, 2020.
Claims priority of provisional application 63/066,141, filed on Aug. 14, 2020.
Prior Publication US 2022/0047872 A1, Feb. 17, 2022
Int. Cl. A61N 1/36 (2006.01); A61N 1/05 (2006.01)
CPC A61N 1/36171 (2013.01) [A61N 1/0534 (2013.01); A61N 1/36067 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method of locating an implantation site in the brain, the method comprising:
inserting a plurality of multi-contact electrode probes into a region of a target structure in an individual's brain, each multi-contact electrode probe of the plurality of multi-contact electrode probes being simultaneously inserted into the region of the target structure to a discrete depth, each multi-contact electrode probe of the plurality of multi-contact electrode probes including a plurality of contacts spaced apart from each other along a length of the multi-contact electrode probe;
applying High Frequency Stimulation (HFS) to a subset of contacts of a multi-contact electrode probe of the plurality of multi-contact electrode probes;
measuring High Frequency Oscillations (HFO) evoked in the region of the target structure by the HFS;
measuring Evoked Compound Activity (ECA) waveform evoked in the region of the target structure by the HFS;
determining if the HFO is above a predetermined threshold;
determining if the ECA waveform is above a predetermined threshold;
if at least one of the HFO or the ECA is above the predetermined threshold, identifying a location of the subset of contacts of the multi-contact electrode probe as a site for electrode implantation in the individual's brain;
determining an amplitude, a phase, and a resonance duration of the measured ECA waveform;
extracting a phase space from the ECA waveform;
determining a stimulation frequency range based on the extracted phase space;
delivering stimulation within the stimulation frequency range;
determining a corresponding power of each frequency of the HFO that is within the stimulation frequency range; and
selecting for treatment a frequency within the stimulation frequency range, wherein the frequency is associated with a maximum power of the powers corresponding to each frequency of the HFO that is within the stimulation frequency range.