CPC C07D 487/04 (2013.01) [A61K 8/4953 (2013.01); A61Q 19/00 (2013.01)] | 15 Claims |
1. A compound of formula (I):
![]() or a cosmeceutically acceptable or pharmaceutically acceptable salt thereof,
wherein:
L is —C(O)— or —S(O)2—;
X is —C(O)— or —CH2C(O)—;
Y is H or C(O)R;
R is C1-30 alkyl or C2-30 alkenyl;
R1 is H or CH3;
R2 is H or CH3;
R3 is H or D;
Q is benzyl, phenyl, or an 8- to 11-membered aryl;
wherein the 8- to 11-membered aryl is bicyclic;
wherein the 8- to 11-membered aryl optionally contains 1, 2, or 3 heteroatoms independently selected from the group consisting of nitrogen, oxygen, and sulfur;
wherein the benzyl is optionally substituted with one or more substituents independently selected from the group consisting of halogen, CN, NO2, C1-4 perfluoroalkyl, C(NH)NH2, C(O)OH, NH2, NHC1-4 alkyl, N(C1-4 alkyl)2, NHC(NH)NH2, OH, OC1-3 alkyl, S(O)2alkyl, S(O)2heterocyclyl, and S(O)2aryl; and
wherein the phenyl is optionally substituted with one or more substituents independently selected from the group consisting of halogen, CN, NO2, C1-4 alkyl, C1-4 perfluoroalkyl, C(NH)NH2, C(O)OH, NH2, NHC1-4 alkyl, N(C1-4 alkyl)2, NHC(NH)NH2, OH, OC1-3 alkyl, S(O)2alkyl, S(O)2heterocyclyl, and S(O)2aryl; and
n is 1 or 2.
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3. A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of claim 1, or a pharmaceutically acceptable salt thereof.
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