CPC A61K 31/70 (2013.01) [A61K 31/47 (2013.01); A61K 31/4709 (2013.01); A61K 31/7052 (2013.01)] | 17 Claims |
1. A method for enhancing telomerase reverse transcriptase (TERT) expression in a cell, the method comprising:
contacting the cell with a TERT expression enhancing effective amount of a compound, wherein the compound is
A) of the structure of formula (II):
![]() wherein R1 is selected from hydroxyl, an alkoxy, an aryloxy, an acyloxy and OR101, where R101 is a sugar or sugar derivative;
R2 is selected from hydrogen, an aliphatic, an aryl, an alkoxy, an aryloxy, an acyloxy, an amino, a carbonyl, a cyano, a heterocycle, a hydroxyl, a nitro, a thio, a sulfinyl and a sulfonyl; and
R3, R4, R5, R6 and R7 are independently selected from hydrogen, an aliphatic, an aryl, an alkoxy, an aryloxy, an acyloxy, an amino, a carbonyl, a cyano, a halogen, a heterocycle, a hydroxyl, a nitro, a thio, a sulfinyl and a sulfonyl
wherein at least three of R2, R3, R4, R5, R6 and R7 are not hydrogen;
or
B) of the structure of formula (II):
![]() wherein R1 is selected from hydroxyl, an alkoxy, an aryloxy, an acyloxy and OR101, where R101 is a sugar or sugar derivative;
R4 is selected from hydrogen, an aliphatic, an aryl, an alkoxy, an aryloxy, an acyloxy, an amino, a carbonyl, a cyano, a heterocycle, a hydroxyl, a nitro, a thio, a sulfinyl and a sulfonyl; and
R2, R3, R5, R6 and R7 are independently selected from hydrogen, an aliphatic, an aryl, an alkoxy, an aryloxy, an acyloxy, an amino, a carbonyl, a cyano, a halogen, a heterocycle, a hydroxyl, a nitro, a thio, a sulfinyl and a sulfonyl;
wherein at least three of R2, R3, R4, R5, R6 and R7 are not hydrogen.
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