CPC C07K 16/30 (2013.01) [C07K 16/2809 (2013.01); C07K 16/468 (2013.01); C07K 2317/31 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01)] | 6 Claims |
1. A bispecific antibody, comprising
an anti-TAG72 single chain variable fragment (scFv) antibody that specifically binds human TAG72 linked to an anti-CD3 scFv that specifically binds human CD3 epsilon subunit,
wherein the anti-TAG72 scFv comprises a variable heavy (VH) domain and a variable light (VL) domain separated by a peptide linker,
wherein the VH domain comprises CDR1, CDR2 and CDR3 domains having the amino acid sequences of SEQ ID NOs: 12, 13 and 14, respectively, and
wherein the VL domain comprises CDR1, CDR2 and CDR3 domains having the amino acid sequences of SEQ ID NOs: 15, 16 and 17, respectively.
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