US 12,168,700 B2
Therapeutic use of mitochondria and combined mitochondrial agents
James D. McCully, Marblehead, MA (US); Sidney Levitsky, Boston, MA (US); Douglas B. Cowan, West Roxbury, MA (US); Pedro J. del Nido, Lexington, MA (US); and Sitaram M. Emani, Boston, MA (US)
Assigned to Children's Medical Center Corporation, Boston, MA (US); and Beth Israel Deaconess Medical Center, Inc., Boston, MA (US)
Filed by Children's Medical Center Corporation, Boston, MA (US); and Beth Israel Deaconess Medical Center, Inc., Boston, MA (US)
Filed on Sep. 1, 2023, as Appl. No. 18/459,892.
Application 16/451,910 is a division of application No. 15/803,543, filed on Nov. 3, 2017, granted, now 10,370,458, issued on Aug. 6, 2019.
Application 18/459,892 is a continuation of application No. 17/960,994, filed on Oct. 6, 2022.
Application 17/960,994 is a continuation of application No. 16/451,910, filed on Jun. 25, 2019, abandoned.
Application 15/803,543 is a continuation of application No. PCT/US2017/013564, filed on Jan. 13, 2017.
Claims priority of provisional application 62/420,381, filed on Nov. 10, 2016.
Claims priority of provisional application 62/279,489, filed on Jan. 15, 2016.
Claims priority of provisional application 62/279,442, filed on Jan. 15, 2016.
Prior Publication US 2023/0416413 A1, Dec. 28, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 16/46 (2006.01); A61B 6/42 (2024.01); A61B 6/50 (2024.01); A61B 8/08 (2006.01); A61K 9/00 (2006.01); A61K 35/12 (2015.01); A61K 35/28 (2015.01); A61K 35/34 (2015.01); A61K 39/00 (2006.01); A61K 47/69 (2017.01); A61K 49/00 (2006.01); A61K 49/18 (2006.01); A61K 51/04 (2006.01); A61K 51/12 (2006.01); C12N 15/11 (2006.01)
CPC C07K 16/468 (2013.01) [A61B 6/42 (2013.01); A61K 9/0019 (2013.01); A61K 35/12 (2013.01); A61K 35/28 (2013.01); A61K 35/34 (2013.01); A61K 47/6901 (2017.08); A61K 49/0002 (2013.01); A61K 49/1821 (2013.01); A61K 49/1896 (2013.01); A61K 51/0421 (2013.01); A61K 51/1203 (2013.01); A61K 51/1282 (2013.01); C12N 15/11 (2013.01); A61B 6/503 (2013.01); A61B 8/0883 (2013.01); A61K 2039/505 (2013.01)] 24 Claims
 
1. A method of transplanting an organ into a human subject, the method comprising:
contacting the organ with an effective amount of a composition comprising exogenous mitochondria such that the mitochondria are incorporated within the organ to generate a modified organ comprising the exogenous mitochondria;
and transplanting the organ to the human subject.