CPC A61K 41/0033 (2013.01) [A61K 9/0019 (2013.01); A61K 31/197 (2013.01); A61M 37/0092 (2013.01); A61N 7/00 (2013.01); A61P 35/00 (2018.01); A61M 2205/6054 (2013.01); A61N 2007/0039 (2013.01)] | 29 Claims |
1. A method for treating diffuse intrinsic pontine glioma in a human subject in need thereof, the method comprising:
a) intravenously administering from 5 mg/kg to 750 mg/kg of gamma-irradiated 5-aminolevulinic acid (5-ALA), or a pharmaceutically acceptable salt thereof, to the subject; and
b) exposing diffuse intrinsic pontine glioma tissue in the subject to ultrasound energy by sonicating the tissue at a plurality of individual points using a focused ultrasound (FUS) device at a frequency of about 0.1 MHz to about 3 MHz and an intensity at an ultrasound beam focus of about 3 W/cm2 to about 100 W/cm2.
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