CPC A61K 38/204 (2013.01) [A61K 38/1709 (2013.01); A61K 38/18 (2013.01); A61K 38/1808 (2013.01); A61K 38/1825 (2013.01); A61K 38/1833 (2013.01); A61K 38/185 (2013.01); A61K 38/1858 (2013.01); A61K 38/1866 (2013.01); A61K 38/1875 (2013.01); A61K 38/1891 (2013.01); A61K 38/19 (2013.01); A61K 38/193 (2013.01); A61K 38/2006 (2013.01); A61K 38/22 (2013.01); G01N 33/74 (2013.01); G01N 33/84 (2013.01); G01N 2333/50 (2013.01); G01N 2333/96486 (2013.01); G01N 2800/10 (2013.01); G01N 2800/105 (2013.01)] | 14 Claims |
1. A method of treating a patient having ischemic tissue resulting from diminished microvascular blood flow consisting of:
identifying a patient with ischemic tissue resulting from diminished microvascular blood flow;
obtaining a vascular anatomy image and a dynamic perfusion image of a hypoperfused tissue of the patient;
calculating an ischemic index from the vascular anatomy image and the dynamic perfusion image, wherein the ischemic index identifies an extent of degeneration and a degree of segmental artery stenosis to determine diminished microvascular blood flow within the hypoperfused tissue portion;
administering a composition consisting of a carrier solution with FGF-1 at 0.1 to 400 μg and at least one member of the group consisting of allograft tissue, synthetic allograft tissue, treated allograft tissue and xenograft tissue, wherein the carrier solution adheres to an anatomical structure of the patient proximal to the ischemic tissue resulting from diminished microvascular blood flow; and
applying the composition to the anatomical structure of the patient proximal to the ischemic tissue resulting from the diminished microvascular blood flow, thereby inducing angiogenesis of capillaries within at least a portion of the ischemic tissue.
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