CPC C07D 487/04 (2013.01) [A61P 27/02 (2018.01); C07D 519/00 (2013.01)] | 20 Claims |
1. A compound having the structure:
![]() wherein
R1, R2, R3, R4, and R5 are each independently H, halogen, alkyl, haloalkyl, O-haloalkyl, aryl or heteroaryl;
X is N or CR6,
wherein Re is H, OH, or halogen;
A is absent or present, and when present is
![]() B has the structure:
![]() wherein
α and β are each a bond that is present or absent;
X1 is N, NH or NR10,
wherein R10 is alkyl, alkenyl or alkynyl;
X2 is C or N;
X3 is CH or N;
R7, R8 and R9 are each, independently, H, halogen, alkyl, alkenyl, alkynyl, alkyl-OH, alkyl-NH2, alkyl-OAc alkyl-O(CO)-alkyl, alkyl-O-alkyl, haloalkyl, cycloalkyl, O-alkyl, NH-alkyl, C(O)OH, C(O)—NH2, C(O)—N(CH3)2, C(O)—NHCH3, NHC(O)—N(CH3)2, CN or CF3,
wherein
X1, X2 and X3 are each N, α is present and β is absent; or
X1 is NH, X2 is C, X3 is CH, α is absent and β is present; or
X1 is N, X2 is N, X3 is CH, α is present and β is absent; or
X1 is NH or NR10, X2 is C, X3 is N, α is absent and β is present, wherein when X1 is NH, X2 is C, X3 is N, α is absent and β is present, then one of R7, R8 and R9 is other than H,
or B has the structure:
![]() wherein
X4 and X5 are each, independently, is N or CH; and
R11, R12 and R13 are each, independently, H, halogen, alkyl, alkenyl, alkynyl, alkyl-OH, alkyl-NH2, alkyl-OAc, alkyl-O(CO)-alkyl, alkyl-O-alkyl, haloalkyl, cycloalkyl, O-alkyl, NH-alkyl, C(O)OH, C(O)—NH2, C(O)—N(CH3)2, C(O)—NHCH3, NHC(O)—N(CH3)2, CN or CF3,
or a pharmaceutically acceptable salt thereof.
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