CPC C07C 205/37 (2013.01) [A61K 31/085 (2013.01); C07J 41/0055 (2013.01)] | 9 Claims |
1. A method of ameliorating a disease or disorder in a subject in need thereof,
wherein the disease or disorder is at least one selected from the group consisting of non- alcoholic fatty liver disease (NAFLD), metabolic syndrome, and diabetes,
the method comprising:
administering to the subject a therapeutically effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof:
![]() wherein:
R1, R2, and R3 are H;
X1 is OR4,
R4 is independently selected from the group consisting of —C1-C3 alkyl -(aryl), —C1-C3 alkyl-(C3-C6 cycloalkyl), and —C1-C3 alkyl-heteroaryl;
wherein the aryl is selected from the group consisting of phenyl and naphthyl;
wherein the heteroaryl is selected from the group consisting of thienyl, furyl, pyrrolyl, imidazolyl, thiazolyl, oxazolyl, pyrazolyl, isothiazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,3,4-triazolyl, 1,2,3-thiadiazolyl, 1,2,3-oxadiazolyl, 1,3,4-thiadiazolyl, and 1,3,4-oxadiazolyl; and
wherein the aryl, cycloalkyl, or heteroaryl is independently optionally substituted by at least one substituent selected from the group consisting of C1-6 alkyl, C1-6 alkoxy, halogen, acetamido, —CN, —NH2, —OH, —NH (CH3), —N (CH3)2, —CF3, —CH2CF3, —OCF3, —OCH2CF3, and nitro.
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