US 12,168,135 B2
Methods, systems, and apparatus for closed-loop neuromodulation
Nicholas Lachlan Opie, Melbourne (AU); Thomas James Oxley, New York, NY (US); and Gil Simon Rind, Parkville (AU)
Assigned to Synchron Australia Pty Limited, Melbourne (AU); and The University of Melbourne, Melbourne (AU)
Filed by Synchron Australia Pty Limited, Melbourne (AU); and The University of Melbourne, The University of Melbourne (AU)
Filed on Apr. 28, 2023, as Appl. No. 18/309,073.
Application 18/309,073 is a division of application No. 17/659,381, filed on Apr. 15, 2022, granted, now 11,672,986.
Application 17/659,381 is a division of application No. 17/398,854, filed on Aug. 10, 2021, granted, now 11,883,671, issued on Jun. 13, 2023.
Application 17/398,854 is a continuation of application No. PCT/US2020/059509, filed on Nov. 6, 2020.
Claims priority of provisional application 63/062,633, filed on Aug. 7, 2020.
Prior Publication US 2023/0302282 A1, Sep. 28, 2023
Int. Cl. A61N 1/36 (2006.01); A61N 1/375 (2006.01); A61N 1/378 (2006.01)
CPC A61N 1/36189 (2013.01) [A61N 1/36053 (2013.01); A61N 1/36064 (2013.01); A61N 1/36175 (2013.01); A61N 1/37514 (2017.08); A61N 1/37516 (2017.08); A61N 1/3787 (2013.01)] 5 Claims
OG exemplary drawing
 
1. A method of treating epilepsy, comprising:
detecting, using a first electrode array, an electrophysiological signal of a subject, wherein the first electrode array is coupled to a first endovascular carrier implanted within the subject in at least one of a superior sagittal sinus, an inferior sagittal sinus, a sigmoid sinus, a transverse sinus, and a straight sinus of the subject;
analyzing the electrophysiological signal using a neuromodulation unit implanted within the subject and electrically coupled to the first electrode array; and
stimulating an intracorporeal target of the subject using a second electrode array in response to the electrophysiological signal detected, wherein the second electrode array is electrically coupled to the neuromodulation unit, and wherein the second electrode array is coupled to a second endovascular carrier implanted within at least one of a vein of Labbe, a vein of Trolard, a Sylvian vein, and a Rolandic vein of the subject.