US 12,168,667 B2
Anti-tumor compound and preparation method and use thereof
Yu Zhang, Shanghai (CN); Zhongyuan Zhu, Shanghai (CN); Haiqing Hua, Shanghai (CN); Bing Li, Shanghai (CN); Jian Li, Shanghai (CN); Shengchao Lin, Shanghai (CN); Xi Li, Shanghai (CN); and Hongxia Shen, Shanghai (CN)
Assigned to DUALITY BIOLOGICS (SUZHOU) CO., LTD., Shanghai (CN)
Filed by DUALITY BIOLOGICS (SUZHOU) CO., LTD., Shanghai (CN)
Filed on Nov. 10, 2023, as Appl. No. 18/506,610.
Application 18/506,610 is a continuation of application No. 18/187,935, filed on Mar. 22, 2023.
Application 18/187,935 is a continuation of application No. 17/825,090, filed on May 26, 2022, granted, now 11,685,742, issued on Jun. 27, 2023.
Application 17/825,090 is a continuation of application No. PCT/CN2021/121721, filed on Sep. 29, 2021.
Claims priority of application No. 202011061580.7 (CN), filed on Sep. 30, 2020.
Prior Publication US 2024/0174686 A1, May 30, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 491/22 (2006.01); A61K 47/65 (2017.01); A61K 47/68 (2017.01); A61P 35/00 (2006.01)
CPC C07D 491/22 (2013.01) [A61K 47/65 (2017.08); A61K 47/68037 (2023.08); A61K 47/6855 (2017.08)] 17 Claims
 
1. An antibody-drug conjugate having a structure:

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof,
wherein n is the connection number, and n is selected from the group consisting of 1 to 10.