CPC A61K 39/04 (2013.01) [A61P 31/06 (2018.01); C12N 5/0636 (2013.01); A61K 2039/5158 (2013.01); A61K 2039/70 (2013.01); C12N 2501/2304 (2013.01); C12N 2501/2307 (2013.01); C12N 2501/2315 (2013.01); C12N 2501/2321 (2013.01); C12N 2501/24 (2013.01); C12N 2501/25 (2013.01)] | 3 Claims |
1. A method of expanding T cells ex vivo, the method comprising:
culturing one or a plurality of T-cells;
contacting the one or plurality of T-cells with:
a polypeptide comprising an amino acid sequence coding for an Ag85B antigen at least 70% identical to SEQ ID NO: 6 from a Mycobacterium species,
a polypeptide comprising an amino acid sequence coding for a PPE68 antigen at least 70% identical to SEQ ID NO: 7 from a Mycobacterium species,
a polypeptide comprising an amino acid sequence coding for an ESXA antigen at least 70% identical to SEQ ID NO: 8 from a Mycobacterium species,
a polypeptide comprising an amino acid sequence coding for an ESXB antigen at least 70% identical to SEQ ID NO: 9 from a Mycobacterium species, and
a polypeptide comprising an amino acid sequence coding for an ADK antigen at least 70% identical to SEQ ID NO: 10 from a Mycobacterium species.
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