Therapeutic use of mitochondria and combined mitochondrial agents
James D. McCully, Marblehead, MA (US); Sidney Levitsky, Boston, MA (US); Douglas B. Cowan, West Roxbury, MA (US); Pedro J. del Nido, Lexington, MA (US); and Sitaram M. Emani, Boston, MA (US)
Assigned to Children's Medical Center Corporation, Boston, MA (US); and Beth Israel Deaconess Medical Center, Inc., Boston, MA (US)
Filed by Children's Medical Center Corporation, Boston, MA (US); and Beth Israel Deaconess Medical Center, Inc., Boston, MA (US)
Filed on Sep. 1, 2023, as Appl. No. 18/459,892.
Application 16/451,910 is a division of application No. 15/803,543, filed on Nov. 3, 2017, granted, now 10,370,458, issued on Aug. 6, 2019.
Application 18/459,892 is a continuation of application No. 17/960,994, filed on Oct. 6, 2022.
Application 17/960,994 is a continuation of application No. 16/451,910, filed on Jun. 25, 2019, abandoned.
Application 15/803,543 is a continuation of application No. PCT/US2017/013564, filed on Jan. 13, 2017.
Claims priority of provisional application 62/420,381, filed on Nov. 10, 2016.
Claims priority of provisional application 62/279,489, filed on Jan. 15, 2016.
Claims priority of provisional application 62/279,442, filed on Jan. 15, 2016.
Prior Publication US 2023/0416413 A1, Dec. 28, 2023
1. A method of transplanting an organ into a human subject, the method comprising:
contacting the organ with an effective amount of a composition comprising exogenous mitochondria such that the mitochondria are incorporated within the organ to generate a modified organ comprising the exogenous mitochondria;