CPC C07K 14/70503 (2013.01) [G01N 33/56983 (2013.01); G01N 33/6854 (2013.01); C07K 2319/00 (2013.01); G01N 2333/08 (2013.01); G01N 2333/10 (2013.01); G01N 2333/16 (2013.01); G01N 2333/70535 (2013.01); G01N 2469/20 (2013.01); G01N 2800/06 (2013.01)] | 9 Claims |
1. A method for assessing levels of a polymeric Ig Receptor (pIgR)-dimeric IgA antibody (dIgA) complex; the method comprising: contacting a biological sample from a subject comprising antibodies with a pIgR comprising in order from N-terminus to C-terminus a rabbit pIgR domain 1 and human pIgR domains 2 to 5, wherein the pIgR binds to dIgA, and assessing the level of the pIgR-dIgA complex, wherein the pIgR does not comprise a transmembrane domain, wherein the pIgR is bound to a solid support, and wherein an elevated level of pIgR-dIgA relative to a reference sample is used to diagnose a subject as having an acute infection selected from the group consisting of hepatitis A virus (HAV), hepatitis C virus (HCV), hepatitis E virus (HEV), and human immunodeficiency virus (HIV), and/or wherein the level of pIgR-dIgA is used to monitor an infection or condition selected from the group consisting of ulcerative colitis, HIV, IBS, leaky gut syndrome, leprosy, syphilis, HAV, HCV, HEV, dengue virus, measles, and rubella.
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