US 12,167,919 B2
System and method for non-invasive, intracranial brain motion monitoring
Quan Zhang, Winchester, MA (US); and Gary Strangman, Boxford, MA (US)
Assigned to The General Hospital Corporation, Boston, MA (US)
Filed by The General Hospital Corporation, Boston, MA (US)
Filed on Dec. 13, 2023, as Appl. No. 18/538,583.
Application 18/538,583 is a division of application No. 17/863,002, filed on Jul. 12, 2022, granted, now 11,883,182.
Application 17/863,002 is a division of application No. 16/710,095, filed on Dec. 11, 2019, granted, now 11,412,976, issued on Aug. 16, 2022.
Application 16/710,095 is a division of application No. 14/900,840, granted, now 10,537,275, issued on Jan. 21, 2020, previously published as PCT/US2014/044056, filed on Jun. 25, 2014.
Claims priority of provisional application 61/889,273, filed on Oct. 10, 2013.
Claims priority of provisional application 61/839,053, filed on Jun. 25, 2013.
Prior Publication US 2024/0115187 A1, Apr. 11, 2024
Int. Cl. A61B 5/00 (2006.01); A61B 5/1455 (2006.01)
CPC A61B 5/4064 (2013.01) [A61B 5/0075 (2013.01); A61B 5/14553 (2013.01); A61B 5/6814 (2013.01)] 20 Claims
OG exemplary drawing
 
20. A method for assessing motion of a biological tissue of a subject, the biological tissue comprising one or more superficial biological layers and a targeted biological layer, the method comprising:
providing one or more wearable elements configured to be arranged on the subject, the one or more wearable elements configured to allow transmission or reception of optical signals to and from the subject at one or more near-infrared wavelengths;
providing an optical perturbation to the one or more superficial biological layers;
transmitting optical signals at the one or more near-infrared wavelengths via the one or more wearable elements;
acquiring a set of optical signal data from the one or more wearable elements preceding, during, or following the optical perturbation at a first acquisition time relative to the optical perturbation; determining, using the set of optical signal data, a set of optical characteristics representative of light transiting the one or more superficial biological layers and the targeted biological tissue;
separating, using the set of optical characteristics and a model of the one or more superficial biological layers and the targeted biological layer, a target optical signal consistent with the targeted biological layer; and
generating a report indicative of a movement of the targeted biological tissue within the subject, wherein the movement of the targeted biological layer is calculated using the target optical signal.