US 12,168,082 B2
Composition for regeneration of human fibrous cartilage or elastic cartilage
Seung Uk An, Paju-si (KR)
Assigned to Medicrinia, Co., Ltd., Seoul (KR)
Appl. No. 16/958,843
Filed by Medicrinia, Co., Ltd., Seoul (KR)
PCT Filed Dec. 28, 2018, PCT No. PCT/KR2018/016892
§ 371(c)(1), (2) Date Jun. 29, 2020,
PCT Pub. No. WO2019/132604, PCT Pub. Date Jul. 4, 2019.
Claims priority of application No. 10-2017-0183688 (KR), filed on Dec. 29, 2017.
Prior Publication US 2021/0069376 A1, Mar. 11, 2021
Int. Cl. A61L 27/22 (2006.01); A61L 27/18 (2006.01); A61L 27/36 (2006.01); A61L 27/52 (2006.01); A61L 27/54 (2006.01); C08L 71/02 (2006.01)
CPC A61L 27/225 (2013.01) [A61L 27/18 (2013.01); A61L 27/3616 (2013.01); A61L 27/3654 (2013.01); A61L 27/3687 (2013.01); A61L 27/52 (2013.01); A61L 27/54 (2013.01); C08L 71/02 (2013.01); A61L 2300/254 (2013.01); A61L 2430/06 (2013.01)] 6 Claims
 
1. A method for regeneration of fibrous cartilage or elastic cartilage, the method comprising administering a composition including hydrogel consisting of: fibrin; and a polyethylene oxide (PEO) or poloxamer as physiologically-active polymer, wherein the physiologically-active polymer and the fibrin form an interpenetrating polymer network (IPN) structure, wherein the hydrogel has a trypsin decomposition resistance.