CPC A61K 31/407 (2013.01) [A61K 9/0048 (2013.01); A61K 31/137 (2013.01); A61K 31/192 (2013.01); A61K 31/405 (2013.01); A61K 31/4174 (2013.01)] | 7 Claims |
1. A method for inhibiting a postoperative inflammatory condition following an ophthalmologic surgical procedure in a subject identified as having an elevated risk of suffering from a postoperative inflammatory condition because of a preoperative physiologic condition, a preoperative treatment history, surgical trauma, or the surgical placement of a device that is associated with an enhanced incidence of postoperative inflammation, the method comprising: administering intracamerally to the subject during an ophthalmologic surgical procedure an effective amount of a solution including ketorolac and phenylephrine in an intraocular irrigation carrier, wherein the effective amount is the amount of the solution sufficient for uptake of an amount of ketorolac in ocular tissues sufficient for at least 90% inhibition of baseline cyclooxygenase-1 and cyclooxygenase-2 activity levels in ocular tissues for a period of at least six hours postoperatively, wherein the postoperative inflammatory condition is cystoid macular edema or uveitis.
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