US 12,168,075 B2
Systems comprising a composite backing and methods for long term transdermal administration
Eun Soo Lee, Redwood City, CA (US); Amit K. Jain, Milpitas, CA (US); and Parminder Singh, Union City, CA (US)
Assigned to Corium, LLC, Cambridge, MA (US)
Filed by Corium, LLC, Boston, MA (US)
Filed on May 4, 2023, as Appl. No. 18/312,129.
Application 18/312,129 is a continuation of application No. 17/200,481, filed on Mar. 12, 2021, granted, now 11,679,086.
Application 17/200,481 is a continuation of application No. 15/396,236, filed on Dec. 30, 2016, granted, now 10,966,936, issued on Apr. 6, 2021.
Claims priority of provisional application 62/367,055, filed on Jul. 26, 2016.
Claims priority of provisional application 62/273,288, filed on Dec. 30, 2015.
Prior Publication US 2024/0108587 A1, Apr. 4, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/70 (2006.01); A61K 9/00 (2006.01); A61K 41/00 (2020.01); A61K 47/34 (2017.01); A61M 35/00 (2006.01)
CPC A61K 9/7084 (2013.01) [A61K 9/0014 (2013.01); A61K 9/7053 (2013.01); A61K 9/7061 (2013.01); A61K 9/7069 (2013.01); A61K 41/00 (2013.01); A61K 47/34 (2013.01); A61M 35/00 (2013.01); A61K 9/703 (2013.01)] 11 Claims
OG exemplary drawing
 
1. A method for treating Alzheimer's disease in a subject, comprising:
applying a transdermal patch to skin of the subject, wherein the transdermal patch is comprised of
a composite backing layer comprised of
(i) a first layer comprised of a polymer fabric or a polymer film comprised of one or more polymers selected from polyesters, and polyethylenes;
(ii) a second layer comprised of one or more adhesive polymers, the one or more adhesive polymers being acrylate copolymers; and
(iii) a third layer comprised of a polyethylene terephthalate/ethylene-vinyl acetate laminate;
wherein the first and second layers are in contact and the second and third layers are in contact, and
wherein the third layer comprises cuts formed at least partially through the third layer; and
an adhesive matrix drug layer laminated to the third layer, the adhesive matrix drug layer comprising donepezil.