CPC A61K 39/39541 (2013.01) [A61K 9/0053 (2013.01); A61K 31/4406 (2013.01); A61P 35/00 (2018.01); C07K 16/2866 (2013.01); A61K 2039/505 (2013.01); A61K 2039/545 (2013.01); C07K 2317/24 (2013.01); C07K 2317/565 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01)] | 22 Claims |
1. A method of treating cancer, wherein the method comprises administering to a patient a combination comprising entinostat and an anti-CSF-1R antibody or an antigen-binding fragment thereof, wherein the anti-CSF-1R antibody or the antigen-binding fragment thereof comprises:
(a) a heavy chain, wherein the variable domain of the heavy chain comprises a CDR having the sequence given in SEQ ID NO:4 for CDR-H1, a CDR having the sequence given in SEQ ID NO:5 for CDR-H2 and a CDR having the sequence given in SEQ ID NO:6 for CDR-H3; and
(b) a light chain, wherein the variable domain of the light chain comprises a CDR having the sequence given in SEQ ID NO: 1 for CDR-L1, a CDR having the sequence given in SEQ ID NO:2 for CDR-L2 and a CDR having the sequence given in SEQ ID NO: 3 for CDR-L3.
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