US 12,169,034 B2
Method for pressure control in crossflow filtration
Klaus Gebauer, Uppsala (SE); Sudheer Mygapula, Bangalore (IN); Nachiket Karmarkar, Bangalore (IN); Sasikumar Arumugam, Bangalore (IN); Bashkar Hv, Bangalore (IN); Ajit S. Vernekar, Bangalore (IN); Nityananda Maiya, Bangalore (IN); Prashanth Hosabettu Mohan, Bangalore (IN); Sasi Kumar Nutalapati, Bangalore (IN); Sameera Simha Hindupur, Bangalore (IN); and Shashidhar Hedge, Bangalore (IN)
Assigned to Cytiva Sweden AB, Uppsala (SE)
Appl. No. 16/077,779
Filed by Cytiva Sweden AB, Uppsala (SE)
PCT Filed Feb. 21, 2017, PCT No. PCT/EP2017/053874
§ 371(c)(1), (2) Date Aug. 14, 2018,
PCT Pub. No. WO2017/144440, PCT Pub. Date Aug. 31, 2017.
Claims priority of application No. 201611006767 (IN), filed on Feb. 26, 2016.
Prior Publication US 2020/0282361 A1, Sep. 10, 2020
Int. Cl. F16K 7/06 (2006.01); B01D 61/12 (2006.01); B01D 61/22 (2006.01); F16K 7/07 (2006.01); G05D 16/20 (2006.01)
CPC F16K 7/06 (2013.01) [B01D 61/12 (2013.01); B01D 61/22 (2013.01); F16K 7/07 (2013.01); G05D 16/2013 (2013.01); B01D 2311/04 (2013.01); B01D 2311/08 (2013.01); B01D 2311/14 (2013.01); B01D 2313/18 (2013.01)] 9 Claims
OG exemplary drawing
 
1. A crossflow filtration apparatus comprising a crossflow filter and a throttling assembly, the throttling assembly comprising:
a pump fluidically connected to a length of flexible tubing mounted in the pinch valve, the length of flexible tubing being coupled to the crossflow filter, the pinch valve comprising:
a valve body with a tubing holder,
a valve seat,
an actuator adapted to compress the flexible tubing in said tubing holder against said valve seat, and
a pneumatic or hydraulic actuator drive, and
a first pressure transducer adapted to measure a pressure in said length of tubing between said pump and said pinch valve, and
wherein the actuator is configured to move between a plurality of actuator positions at variable actuator velocities.