CPC A61K 9/14 (2013.01) [A61K 9/0075 (2013.01); A61K 31/5575 (2013.01); A61K 45/06 (2013.01)] | 21 Claims |
1. A compound having the following formula:
![]() wherein X is a salt moiety or a promoiety; wherein each of OR2 and OR3 has a lower reactivity with a carboxyl group than that of the respective hydroxyl group of unsubstituted treprostinil and C═OX has a lower reactivity with hydroxyl than that of the carboxyl group of unsubstituted treprostinil, wherein R2 and R3 are each independently selected from CH2OBn, CH2OH,
![]() wherein Z is O or CH2; or wherein R2 and R3 are joined together to form an 8-12 membered heterocyclyl comprising
—C(O)—, —SO2—, or
![]() and wherein
each R10 is H, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 alkenyl, optionally substituted cycloalkyl, optionally substituted heteroaryl, or optionally substituted aryl.
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