US 12,168,053 B2
Microneedle system for applying a hepatitis vaccine
Andreas Henning, Koblenz (DE); and Heiko Spilgies, Koblenz (DE)
Assigned to LTS LOHMANN THERAPIE-SYSTEME AG, Andernach (DE)
Appl. No. 16/762,539
Filed by LTS LOHMANN THERAPIE-SYSTEME AG, Andernach (DE)
PCT Filed Nov. 12, 2018, PCT No. PCT/EP2018/080986
§ 371(c)(1), (2) Date May 8, 2020,
PCT Pub. No. WO2019/092257, PCT Pub. Date May 16, 2019.
Claims priority of application No. 10 2017 126 501.5 (DE), filed on Nov. 10, 2017.
Prior Publication US 2021/0369839 A1, Dec. 2, 2021
Int. Cl. A61K 39/29 (2006.01); A61K 47/10 (2017.01); A61K 47/26 (2006.01); A61K 47/32 (2006.01); A61M 37/00 (2006.01); A61K 9/00 (2006.01)
CPC A61K 39/29 (2013.01) [A61K 47/10 (2013.01); A61K 47/26 (2013.01); A61K 47/32 (2013.01); A61M 37/0015 (2013.01); A61K 9/0021 (2013.01); A61M 2037/0023 (2013.01); A61M 2037/003 (2013.01); A61M 2202/30 (2013.01)] 13 Claims
OG exemplary drawing
 
1. A microneedle array for use in the intradermal application for hepatitis vaccination, wherein the microneedle array consists of HBsAg, and 1 to 95% by weight of polyvinylpyrrolidone and
trehalose 0.1 to 50% by weight as an auxiliary
polysorbate 0.01 to 10% by weight as an auxiliary and
glycerol 0.1 to 10% by weight as an auxiliary.