US 12,168,019 B1
8-hydroxy quinoline derivatives for enhancing telomerase reverse transcriptase (TERT) expression
William H. Andrews, Reno, NV (US); Lancer K. Brown, Sparks, NV (US); Laura A. Briggs, Reno, NV (US); Federico C. A. Gaeta, Mountain View, CA (US); Hamid Mohammadpour, Reno, NV (US); and Mieczyslaw A. Piatyszek, Gainesville, FL (US)
Assigned to Sierra Sciences, Inc., Reno, NV (US)
Filed by Sierra Sciences, Inc., Reno, NV (US)
Filed on Oct. 21, 2022, as Appl. No. 17/970,999.
Application 17/970,999 is a continuation of application No. 13/110,583, filed on May 18, 2011, granted, now 11,701,374.
Claims priority of provisional application 61/345,980, filed on May 18, 2010.
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/70 (2006.01); A61K 31/47 (2006.01); A61K 31/4709 (2006.01); A61K 31/7052 (2006.01)
CPC A61K 31/70 (2013.01) [A61K 31/47 (2013.01); A61K 31/4709 (2013.01); A61K 31/7052 (2013.01)] 17 Claims
 
1. A method for enhancing telomerase reverse transcriptase (TERT) expression in a cell, the method comprising:
contacting the cell with a TERT expression enhancing effective amount of a compound, wherein the compound is
A) of the structure of formula (II):

OG Complex Work Unit Chemistry
wherein R1 is selected from hydroxyl, an alkoxy, an aryloxy, an acyloxy and OR101, where R101 is a sugar or sugar derivative;
R2 is selected from hydrogen, an aliphatic, an aryl, an alkoxy, an aryloxy, an acyloxy, an amino, a carbonyl, a cyano, a heterocycle, a hydroxyl, a nitro, a thio, a sulfinyl and a sulfonyl; and
R3, R4, R5, R6 and R7 are independently selected from hydrogen, an aliphatic, an aryl, an alkoxy, an aryloxy, an acyloxy, an amino, a carbonyl, a cyano, a halogen, a heterocycle, a hydroxyl, a nitro, a thio, a sulfinyl and a sulfonyl
wherein at least three of R2, R3, R4, R5, R6 and R7 are not hydrogen;
or
B) of the structure of formula (II):

OG Complex Work Unit Chemistry
wherein R1 is selected from hydroxyl, an alkoxy, an aryloxy, an acyloxy and OR101, where R101 is a sugar or sugar derivative;
R4 is selected from hydrogen, an aliphatic, an aryl, an alkoxy, an aryloxy, an acyloxy, an amino, a carbonyl, a cyano, a heterocycle, a hydroxyl, a nitro, a thio, a sulfinyl and a sulfonyl; and
R2, R3, R5, R6 and R7 are independently selected from hydrogen, an aliphatic, an aryl, an alkoxy, an aryloxy, an acyloxy, an amino, a carbonyl, a cyano, a halogen, a heterocycle, a hydroxyl, a nitro, a thio, a sulfinyl and a sulfonyl;
wherein at least three of R2, R3, R4, R5, R6 and R7 are not hydrogen.