US 12,168,000 B2
Methods of treating pain
Sagar Munjal, Raleigh, NC (US); and Anirudh Gautam, Raleigh, NC (US)
Assigned to SCILEX HOLDING COMPANY, Palo Alto, CA (US)
Filed by Scilex Holding Company, Palo Alto, CA (US)
Filed on Dec. 27, 2021, as Appl. No. 17/562,229.
Claims priority of provisional application 63/131,172, filed on Dec. 28, 2020.
Prior Publication US 2022/0202776 A1, Jun. 30, 2022
Int. Cl. A61K 31/415 (2006.01); A61P 29/00 (2006.01)
CPC A61K 31/415 (2013.01) [A61P 29/00 (2018.01)] 15 Claims
OG exemplary drawing
 
1. A method of providing a therapeutic regimen for the treatment of acute pain, wherein said method comprises administering an oral liquid pharmaceutical composition comprising celecoxib or a pharmaceutically acceptable salt thereof, to a subject in need thereof, and said therapeutic regimen maintains steady-state maximum plasma concentration (Cmaxss) of not more than about 1400 ng/mL upon oral administration under fasting conditions; wherein said therapeutic regimen comprises administering an initial dose of 200 mg of celecoxib on day 1, followed by subsequent doses of 100 mg of celecoxib after every 6 hours.