US 12,170,433 B2
Amplitude-modulated laser
Michael Bellos, Lebanon, CT (US); Alexander Goryaynov, New Haven, CT (US); Benjamin Cipriany, Branford, CT (US); Xinghua Shi, Madison, CT (US); and Faisal R. Ahmad, Guilford, CT (US)
Assigned to Quantum-Si Incorporated, Branford, CT (US)
Filed by Quantum-Si Incorporated, Guilford, CT (US)
Filed on Jan. 13, 2021, as Appl. No. 17/148,515.
Claims priority of provisional application 62/961,179, filed on Jan. 14, 2020.
Prior Publication US 2021/0218218 A1, Jul. 15, 2021
Int. Cl. H01S 3/098 (2006.01); H01S 3/00 (2006.01); H01S 3/081 (2006.01); H01S 3/10 (2006.01); H01S 3/105 (2006.01); H01S 3/106 (2006.01); H01S 3/107 (2006.01); H01S 3/1115 (2023.01); H01S 3/1118 (2023.01); G01N 21/64 (2006.01)
CPC H01S 3/10038 (2013.01) [H01S 3/0085 (2013.01); H01S 3/0813 (2013.01); H01S 3/105 (2013.01); H01S 3/1068 (2013.01); H01S 3/107 (2013.01); H01S 3/1115 (2013.01); H01S 3/1118 (2013.01); G01N 21/6402 (2013.01); G01N 2021/6421 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A system comprising:
an instrument that receives a removable chip;
the chip comprising:
a plurality of pixels and a waveguide, each pixel including a sample well adapted to receive a sample, and a detector;
the instrument comprising:
a mode-locked laser comprising:
at least one laser diode; and
at least one laser cavity containing at least one gain medium;
wherein the output of the laser is configured to produce a train of laser pulses optimized to produce fluorescence from the sample according to laser parameters whose values are selected based on input representing sample fluorescent material, the train of laser pulses being fed to the chip and delivered by the waveguide as excitation light to each sample well.