US 12,168,056 B2
Scintillator nanocrystal-containing compositions and methods for their use
Milan T. Makale, San Diego, CA (US); Wolfgang J. Wrasidlo, La Jolla, CA (US); Santosh Kesari, La Jolla, CA (US); Joanna McKittrick, La Jolla, CA (US); Gustavo A. Hirata Flores, Ensenada (MX); and Olivia Graeve, La Mesa, CA (US)
Assigned to The Regents of the University of California, Oakland, CA (US)
Filed by The Regents of the University of California, Oakland, CA (US)
Filed on Dec. 29, 2021, as Appl. No. 17/564,812.
Application 17/564,812 is a continuation of application No. 17/099,663, filed on Nov. 16, 2020, granted, now 11,224,656.
Application 17/099,663 is a continuation of application No. 15/052,526, filed on Feb. 24, 2016, granted, now 10,864,272, issued on Dec. 15, 2020.
Application 15/052,526 is a continuation of application No. PCT/US2014/053487, filed on Aug. 29, 2014.
Claims priority of provisional application 61/872,122, filed on Aug. 30, 2013.
Prior Publication US 2022/0265826 A1, Aug. 25, 2022
Int. Cl. A61K 41/00 (2020.01); A61K 31/704 (2006.01); A61K 47/69 (2017.01); A61N 5/06 (2006.01); A61N 5/10 (2006.01)
CPC A61K 41/0042 (2013.01) [A61K 31/704 (2013.01); A61K 47/6923 (2017.08); A61K 47/6929 (2017.08); A61N 5/06 (2013.01); A61N 5/10 (2013.01); A61N 2005/0661 (2013.01); A61N 2005/1098 (2013.01)] 18 Claims
 
1. A composition comprising a scintillator nanocrystal, wherein the scintillator nanocrystal comprises one or more of the following:
(a) LuY:Pr-SiO5;
(b) YAG;
(c) YAG:Pr;
(d) GYGAG:Pr (1%) Ga;
(e) GYGAG:Pr (1%) Gd; or
(f) YAG:Pr (1%)-SiO2; and
wherein the scintillator nanocrystal has a diameter from about 25 nm to about 300 nm.