CPC B01L 3/502715 (2013.01) [B01L 9/527 (2013.01); G01N 35/04 (2013.01); G01N 35/1095 (2013.01); B01L 2200/025 (2013.01); B01L 2200/026 (2013.01); B01L 2200/0689 (2013.01); B01L 2200/143 (2013.01); B01L 2300/0877 (2013.01); B01L 2300/123 (2013.01); G01N 2035/0401 (2013.01); G01N 2035/0475 (2013.01)] | 30 Claims |
1. An apparatus, comprising:
a system, including:
a reagent cartridge receptacle;
a lift plate assembly including a lift plate, a system plunger assembly carried by the lift plate and including a plurality of system plungers, and a lift plate drive assembly operatively coupled to the lift plate;
a flow cell assembly, including:
a flow cell housing having a dimensional envelope;
a flow cell carried by the flow cell housing and including at least one channel, a flow cell inlet, and a flow cell outlet;
a fluidic conduit fluidically coupled to each of the flow cell inlet and the flow cell outlet; and
a gasket assembly disposed within the dimensional envelope of the flow cell housing, the gasket assembly fluidically coupled to the fluidic conduit and having a flow cell inlet gasket and a flow cell outlet gasket, the flow cell inlet gasket having a through bore and being fluidically coupled to the flow cell inlet via the fluidic conduit, the flow cell outlet gasket having a through bore and being fluidically coupled to the flow cell outlet via the fluidic conduit; and
a reagent cartridge receivable within the reagent cartridge receptacle, the reagent cartridge comprising:
a reagent cartridge plunger assembly having a plurality of reagent cartridge plungers, wherein each reagent cartridge plunger is adapted to be aligned with a corresponding system plunger of the system plunger assembly and a corresponding flow cell gasket of the flow cell assembly when the reagent cartridge is received within the reagent cartridge receptacle; and
a pair of reagent cartridge ports adapted to be fluidically coupled to the flow cell inlet gasket and the flow cell outlet gasket,
wherein the lift plate drive assembly is configured to drive movement of the lift plate linearly toward the reagent cartridge so as to cause the system plungers to engage the reagent cartridge plungers, thereby moving the reagent cartridge plungers into engagement with the gasket assembly to allow fluid communication between the pair of reagent cartridge ports and the flow cell via the flow cell inlet and the flow cell outlet.
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