US 12,168,038 B2
Systems and methods for angiogenic treatment in wound healing
Vance Gardner, Irvine, CA (US); Hon Yu, Irvine, CA (US); Kenneth A. Thomas, Chatham, NJ (US); Thomas J. Stegmann, Petersberg (DE); John W. Jacobs, Berkley, CA (US); Tugan Muftuler, Aliso, CA (US); and Shadfar Bahri, Irvine, CA (US)
Assigned to VENTURIS THERAPEUTICS, INC., Dallas, TX (US)
Filed by Venturis Therapeutics, Inc., Dallas, TX (US)
Filed on Apr. 13, 2020, as Appl. No. 16/846,476.
Application 16/846,476 is a continuation of application No. 14/573,153, filed on Dec. 17, 2014, granted, now 10,624,952.
Application 14/573,153 is a continuation of application No. 12/076,846, filed on Mar. 24, 2008, granted, now 8,983,570, issued on Mar. 17, 2015.
Claims priority of provisional application 61/022,266, filed on Jan. 18, 2008.
Claims priority of provisional application 60/920,254, filed on Mar. 27, 2007.
Prior Publication US 2020/0237873 A1, Jul. 30, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 38/00 (2006.01); A61K 38/17 (2006.01); A61K 38/18 (2006.01); A61K 38/19 (2006.01); A61K 38/20 (2006.01); A61K 38/22 (2006.01); G01N 33/74 (2006.01); G01N 33/84 (2006.01)
CPC A61K 38/204 (2013.01) [A61K 38/1709 (2013.01); A61K 38/18 (2013.01); A61K 38/1808 (2013.01); A61K 38/1825 (2013.01); A61K 38/1833 (2013.01); A61K 38/185 (2013.01); A61K 38/1858 (2013.01); A61K 38/1866 (2013.01); A61K 38/1875 (2013.01); A61K 38/1891 (2013.01); A61K 38/19 (2013.01); A61K 38/193 (2013.01); A61K 38/2006 (2013.01); A61K 38/22 (2013.01); G01N 33/74 (2013.01); G01N 33/84 (2013.01); G01N 2333/50 (2013.01); G01N 2333/96486 (2013.01); G01N 2800/10 (2013.01); G01N 2800/105 (2013.01)] 14 Claims
 
1. A method of treating a patient having ischemic tissue resulting from diminished microvascular blood flow consisting of:
identifying a patient with ischemic tissue resulting from diminished microvascular blood flow;
obtaining a vascular anatomy image and a dynamic perfusion image of a hypoperfused tissue of the patient;
calculating an ischemic index from the vascular anatomy image and the dynamic perfusion image, wherein the ischemic index identifies an extent of degeneration and a degree of segmental artery stenosis to determine diminished microvascular blood flow within the hypoperfused tissue portion;
administering a composition consisting of a carrier solution with FGF-1 at 0.1 to 400 μg and at least one member of the group consisting of allograft tissue, synthetic allograft tissue, treated allograft tissue and xenograft tissue, wherein the carrier solution adheres to an anatomical structure of the patient proximal to the ischemic tissue resulting from diminished microvascular blood flow; and
applying the composition to the anatomical structure of the patient proximal to the ischemic tissue resulting from the diminished microvascular blood flow, thereby inducing angiogenesis of capillaries within at least a portion of the ischemic tissue.