US 12,168,653 B2
Sulfonamide derivates as NLRP3 inhibitors
Matthew Cooper, Cambridge (GB); David Miller, Cambridge (GB); Jimmy Van Wiltenburg, Groningen (NL); Jonathan Shannon, Nottingham (GB); and Stephen St-Gallay, Nottingham (GB)
Assigned to INFLAZOME LIMITED, Dublin (IE)
Appl. No. 16/977,464
Filed by Inflazome Limited, Dublin (IE)
PCT Filed Mar. 1, 2019, PCT No. PCT/EP2019/055154
§ 371(c)(1), (2) Date Sep. 1, 2020,
PCT Pub. No. WO2019/166633, PCT Pub. Date Sep. 6, 2019.
Claims priority of application No. 1803417 (GB), filed on Mar. 2, 2018; and application No. 1902326 (GB), filed on Feb. 20, 2019.
Prior Publication US 2020/0407340 A1, Dec. 31, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 401/12 (2006.01); C07C 311/51 (2006.01); C07D 207/14 (2006.01); C07D 213/64 (2006.01)
CPC C07D 401/12 (2013.01) [C07C 311/51 (2013.01); C07D 207/14 (2013.01); C07D 213/64 (2013.01)] 18 Claims
 
1. A compound of formula (I):

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt or solvate thereof, wherein:
Q is selected from O or S;
R1 is a saturated or unsaturated hydrocarbyl group containing from 2 to 25 atoms other than hydrogen, wherein the hydrocarbyl group may be straight-chained or branched or include cyclic groups, wherein the hydrocarbyl group may optionally be substituted, and wherein the hydrocarbyl group may optionally include one or more heteroatoms N or S in its carbon skeleton, provided that the hydrocarbyl group includes at least one heteroatom N or S in its carbon skeleton or is substituted with a substituent comprising at least one heteroatom N, O or S, and provided that the atom of R1 which is attached to the sulfur atom of the remainder of the molecule is not a ring atom of a cyclic group;
R2 is a cyclic group substituted at the α and α′ positions, wherein at least one substituent at the α and/or α′ positions comprises a carbon atom, and wherein R2 may optionally be further substituted;
R3 is hydrogen, halogen, —OH, —NH2, —CN, —R5, —OR5, —NHR5 or —N(R5)2;
R4 is hydrogen, halogen, —OH, —NH2, —CN, —R5, —OR5, —NHR5 or —N(R5)2; and
R5 is independently C1-C4 alkyl.