US 12,168,332 B2
Sampling of bi-layer tablets
Karan Singh, Mumbai (IN); and Amulya Kumar Pati, Mumbai (IN)
Assigned to Scitech Centre, Mumbai (IN); and ACG Pam Pharma Technologies PVT. LTD., Mumbai (IN)
Appl. No. 17/633,420
Filed by Scitech Centre, Mumbai (IN); and ACG Pam Pharma Technologies PVT. LTD., Mumbai (IN)
PCT Filed Aug. 7, 2020, PCT No. PCT/IN2020/050697
§ 371(c)(1), (2) Date Feb. 7, 2022,
PCT Pub. No. WO2021/024276, PCT Pub. Date Feb. 11, 2021.
Claims priority of application No. 201921032047 (IN), filed on Aug. 7, 2019.
Prior Publication US 2022/0281199 A1, Sep. 8, 2022
Int. Cl. B30B 11/00 (2006.01); B30B 11/34 (2006.01); G01N 1/04 (2006.01)
CPC B30B 11/005 (2013.01) [B30B 11/34 (2013.01); G01N 1/04 (2013.01)] 8 Claims
OG exemplary drawing
 
1. A method for sampling both layers of a bi-layer tablet, the method comprising:
forming a first layer of a first pharmaceutical powder of the bi-layer tablet in a tablet press machine;
performing weight compensation for forming a second layer of a second pharmaceutical powder of the bi-layer tablet based at least on the formed first layer;
performing height compensation for forming the second layer of the second pharmaceutical powder of the bi-layer tablet based at least on the formed first layer,
wherein the step of performing height compensation comprises:
(i) determining a cylindrical height for the weight compensated second layer of the bi-layer tablet, wherein the step of determining the cylindrical height of the second layer comprises deducting sum of the cylindrical height of the formed first layer and a second layer height compensation factor, from an actual cylindrical height of the both the first and second layers in the die; and
(ii) displacing a compression means of the tablet press machine by a distance based on the determined cylindrical height for the weight compensated second layer to form a hardened second layer in the die of the tablet press machine; and
forming the second layer of the bi-layer tablet based on the performed height compensation and weight compensation, in the tablet press machine, for individually sampling both the first and second layers of the bi-layer tablet.