US 12,167,732 B2
Alkali-resistant calcium phosphate/nucleic acids hybrid carrier for pest control and method to produce the particles
David Henry, Fontaine le Port (FR); and Valerie Claudine Lacarriere, Larchant (FR)
Assigned to CORNING INCORPORATED, Corning, NY (US)
Filed by CORNING INCORPORATED, Corning, NY (US)
Filed on Dec. 3, 2020, as Appl. No. 17/110,389.
Claims priority of provisional application 62/945,780, filed on Dec. 9, 2019.
Prior Publication US 2021/0169083 A1, Jun. 10, 2021
Int. Cl. A01N 57/16 (2006.01); A01N 25/04 (2006.01); A01N 63/60 (2020.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01)
CPC A01N 57/16 (2013.01) [A01N 25/04 (2013.01); C12N 15/113 (2013.01)] 25 Claims
OG exemplary drawing
 
1. A composition comprising nanoparticles, wherein said nanoparticles comprise a nucleic acid at least partially encapsulated within a matrix comprising calcium phosphate, wherein the composition further comprises a capping agent at least partially coating the nanoparticle, wherein the nanoparticles with the capping agent have a peak particle size range of 150 nm to 500 nm, and the capping agent comprises polyethyleneimine, and wherein either the weight ratio of calcium phosphate to nucleic acid in the nanoparticle is from 100:1 to 1:1.5, or the weight ratio of calcium phosphate to nucleic acid to capping agent in the nanoparticle is 2:1:2 to 2:5:2.