CPC A61K 38/55 (2013.01) [C12N 9/22 (2013.01)] | 14 Claims |
1. A circular zymogen of ribonuclease 1 (RNase 1) having a truncated C-terminus and a truncated N-terminus that are connected by a bridge that comprises a proteolytic cleavage site,
wherein the truncated C-terminus has at least 4 residues truncated and the truncated N-terminus has 1 to 6 residues truncated.
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