CPC C12N 1/16 (2013.01) [A61K 35/646 (2013.01); A61K 39/0003 (2013.01); C07K 14/43527 (2013.01)] | 20 Claims |
1. An isolated polynucleotide comprising a nucleotide sequence encoding an engineered persulcatusin, wherein the engineered persulcatusin comprises a variant of the amino acid sequence of SEQ ID NO: 1, wherein the variant amino acid sequence comprises one or more amino acid substitutions at positions selected from F6, N7, G9, R13, H14, R16, I18, R20, R21, A26, L28, F29, and R38 of SEQ ID NO: 1.
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