US 12,168,674 B1
Reagents and methods for the highly-efficient synthesis and purification of biopolymers
David A. Schwartz, Encinitas, CA (US); and Jimmy H. Williams, Santee, CA (US)
Assigned to Oligo Foundry, Inc., Encinitas, CA (US)
Filed by OLIGO FOUNDRY, INC., Encinitas, CA (US)
Filed on Dec. 8, 2023, as Appl. No. 18/534,413.
Int. Cl. C07H 19/10 (2006.01)
CPC C07H 19/10 (2013.01) 21 Claims
 
1. A reagent compound having a structure:
T′-C′-P′
wherein T′ is a modified trityl protecting group comprising a selectively-reactive linker moiety, C′ is a connecting moiety, and P′ is a phosphoramidite or phosphoramidate,
wherein the selectively-reactive linker moiety comprises an aliphatic or aromatic aldehyde or ketone, an aliphatic or aromatic hydrazide, an aliphatic or aromatic hydrazine, an oxyamino group, or a component of a click reaction.