US 12,168,081 B2
Highly elastic medical sealants for flexible soft tissue
Sai Veruva, Raritan, NJ (US); Salim Ghodbane, Raritan, NJ (US); and Thomas Weindl, Somerville, NJ (US)
Assigned to Ethicon, Inc., Raritan, NJ (US)
Filed by Ethicon, Inc., Raritan, NJ (US)
Filed on May 6, 2022, as Appl. No. 17/738,636.
Prior Publication US 2023/0355831 A1, Nov. 9, 2023
Int. Cl. A61L 24/00 (2006.01); A61L 24/04 (2006.01)
CPC A61L 24/0042 (2013.01) [A61L 24/0026 (2013.01); A61L 24/0031 (2013.01); A61L 24/043 (2013.01); A61L 24/046 (2013.01)] 12 Claims
 
1. A liquid composition for forming a crosslinked sealant for expandable soft tissue comprising:
a reactive hydrogel mixture comprising an electrophilic compound and nucleophilic compound wherein the electrophilic compound includes a multi-arm polyethylene glycol (PEG) based polymer, and wherein the nucleophilic compound includes at least one reactive amine group and the electrophilic compound and nucleophilic compounds are cross-linkable with each other via reaction of the available electrophilic and nucleophilic moieties of each compound;
an amphiphilic poly (akyl) ene glycol block polymer in a range of about 5% to about 15% (w/v) of the sealant composition;
wherein the amphiphilic poly (akyl) ene glycol block polymer is a triblock copolymer consisting of a central block of polypropylene glycol and two end blocks of polyethylene glycol;
and,
a buffer solution having a pH in the range of about 8.5 to about 10.5;
wherein the composition has a final crosslinked hydrogel phase having an ultimate extension in the range of about 15 mm to about 40 mm and an ultimate tensile stress in the range of about 2.4 kPa to 5.9 kPa.