US 12,168,005 B2
Methods for treating wild type isocitrate dehydrogenase 1 cancers
Jordan M. Winter, Shaker Heights, OH (US)
Assigned to UNIVERSITY HOSPITALS CLEVELAND MEDICAL CENTER, Cleveland, OH (US)
Filed by University Hospitals Cleveland Medical Center, Cleveland, OH (US)
Filed on Sep. 24, 2020, as Appl. No. 17/030,844.
Claims priority of provisional application 62/911,717, filed on Oct. 7, 2019.
Prior Publication US 2021/0100780 A1, Apr. 8, 2021
Int. Cl. A61K 31/444 (2006.01); A61P 35/00 (2006.01); G01N 33/50 (2006.01); A61K 45/06 (2006.01)
CPC A61K 31/444 (2013.01) [A61P 35/00 (2018.01); G01N 33/5038 (2013.01); A61K 45/06 (2013.01)] 13 Claims
 
1. A method of treating cancer in a mammalian subject in need thereof, said cancer contains cancer cells characterized by presence of wild type isocitrate dehydrogenase 1 (IDH1) enzyme and absence of mutant IDH1 enzyme, the method comprising
administering to said subject a pharmaceutical composition comprising compound AG-120 having the formula

OG Complex Work Unit Chemistry
and
reducing glucose concentration in blood of said subject.