CPC C07K 14/245 (2013.01) [C12N 15/70 (2013.01); C12P 5/002 (2013.01); C12P 7/42 (2013.01)] | 25 Claims |
1. A modified bacterium comprising a modification to the expression of at least ten genes encoding a type I or type II toxin-antitoxin (TA) system protein (Δ10TA) wherein the modification reduces the activity of a toxin protein or suppresses the effects of a toxin protein, and at least two genes encoding structural proteins that modulate ribosomes selected from rmf (Δrmf), hpf (Δhpf), rsfs (Δrsfs), yqjD (ΔyqjD), elaB (ΔelaB), raiA (ΔraiA), ygaM (ΔygaM), and SRA (ΔSRA), wherein the bacterium is Escherichia coli (E. coli).
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