CPC A61N 1/36171 (2013.01) [A61N 1/0534 (2013.01); A61N 1/36067 (2013.01)] | 20 Claims |
1. A method of locating an implantation site in the brain, the method comprising:
inserting a plurality of multi-contact electrode probes into a region of a target structure in an individual's brain, each multi-contact electrode probe of the plurality of multi-contact electrode probes being simultaneously inserted into the region of the target structure to a discrete depth, each multi-contact electrode probe of the plurality of multi-contact electrode probes including a plurality of contacts spaced apart from each other along a length of the multi-contact electrode probe;
applying High Frequency Stimulation (HFS) to a subset of contacts of a multi-contact electrode probe of the plurality of multi-contact electrode probes;
measuring High Frequency Oscillations (HFO) evoked in the region of the target structure by the HFS;
measuring Evoked Compound Activity (ECA) waveform evoked in the region of the target structure by the HFS;
determining if the HFO is above a predetermined threshold;
determining if the ECA waveform is above a predetermined threshold;
if at least one of the HFO or the ECA is above the predetermined threshold, identifying a location of the subset of contacts of the multi-contact electrode probe as a site for electrode implantation in the individual's brain;
determining an amplitude, a phase, and a resonance duration of the measured ECA waveform;
extracting a phase space from the ECA waveform;
determining a stimulation frequency range based on the extracted phase space;
delivering stimulation within the stimulation frequency range;
determining a corresponding power of each frequency of the HFO that is within the stimulation frequency range; and
selecting for treatment a frequency within the stimulation frequency range, wherein the frequency is associated with a maximum power of the powers corresponding to each frequency of the HFO that is within the stimulation frequency range.
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