US 12,168,763 B2
Microorganisms and methods for reducing bacterial contamination
Steve Good-Sung Wong, Vancouver (CA); and Hendrik Jurgens Jansen Van Vuuren, Brentwood Bay (CA)
Assigned to Melio Peptide Systems Inc., Vancouver (CA)
Filed by Melio Peptide Systems Inc., Vancouver (CA)
Filed on Sep. 8, 2023, as Appl. No. 18/463,747.
Application 18/463,747 is a division of application No. 17/347,413, filed on Jun. 14, 2021, granted, now 11,788,053.
Claims priority of provisional application 63/039,238, filed on Jun. 15, 2020.
Prior Publication US 2024/0093140 A1, Mar. 21, 2024
Int. Cl. A61K 35/646 (2015.01); A61K 39/00 (2006.01); C07K 14/435 (2006.01); C12N 1/16 (2006.01)
CPC C12N 1/16 (2013.01) [A61K 35/646 (2013.01); A61K 39/0003 (2013.01); C07K 14/43527 (2013.01)] 20 Claims
 
1. An isolated polynucleotide comprising a nucleotide sequence encoding an engineered persulcatusin, wherein the engineered persulcatusin comprises a variant of the amino acid sequence of SEQ ID NO: 1, wherein the variant amino acid sequence comprises one or more amino acid substitutions at positions selected from F6, N7, G9, R13, H14, R16, I18, R20, R21, A26, L28, F29, and R38 of SEQ ID NO: 1.