CPC A61K 35/17 (2013.01) [A61P 35/00 (2018.01); C07K 16/2803 (2013.01); G01N 33/57407 (2013.01)] | 37 Claims |
1. A method of reducing the risk of development of a toxicity in a subject, the method comprising:
(a) measuring a sum of products of diameters (SPD) of a tumor of a subject having a cancer at a first time point and a second time point that are each measured prior to administration of a T cell therapy for treatment of a cancer, wherein the subject is a candidate for receiving the T cell therapy, and wherein the fold change of the SPD of the tumor between the first time point and the second time point is about 5 or greater; and
(b) administering to the subject: (i) the T cell therapy, and (ii) an agent capable of reducing the risk of development of a toxicity, wherein the toxicity is cytokine release syndrome (CRS) or neurotoxicity.
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