US 12,168,074 B2
Transdermal therapeutic system for the transdermal administration of guanfacine comprising a silicone polymer
Marco Emgenbroich, Rheinbach (DE); Eva-Marie Prinz, Weissenthurm (DE); Elke Klein, Bad Neuenahr-Ahrweiler (DE); Heike Kluth, Ochtendung (DE); Xavier Thomas, Famars (FR); and Linda Sue Nartker, Midland, MI (US)
Assigned to LTS LOHMANN Therapie-Systeme AG, Andernach (DE); and DDP Specialty Electronic Materials US 9, LLC, Wilmington, DE (US)
Filed by LTS LOHMANN Therapie-Systeme AG, Andernach (DE); and DDP Specialty Electronic Materials US 9, LLC, Wilmington, DE (US)
Filed on Jan. 11, 2023, as Appl. No. 18/152,965.
Application 18/152,965 is a continuation of application No. 16/755,043, granted, now 11,576,874, previously published as PCT/EP2018/077791, filed on Oct. 11, 2018.
Claims priority of provisional application 62/570,746, filed on Oct. 11, 2017.
Claims priority of application No. 17205543 (EP), filed on Dec. 5, 2017.
Prior Publication US 2023/0241004 A1, Aug. 3, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/70 (2006.01); A61K 31/165 (2006.01)
CPC A61K 9/7069 (2013.01) [A61K 31/165 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A transdermal therapeutic system for the transdermal administration of guanfacine comprising a guanfacine-containing layer structure, said guanfacine-containing layer structure comprising:
A) a backing layer; and
B) a guanfacine-containing layer;
wherein the guanfacine-containing layer comprises a first silicone polymer in an amount of from 50 to 70% by weight based on the total weight of the guanfacine containing layer, and a second silicone polymer in an amount of from 15 to 45% by weight based on the total weight of the guanfacine-containing layer.