US 12,168,719 B2
Composition of thermosensitive hydrogels having altered reversible sol-gel transition property, and use thereof
Soo Chang Song, Seoul (KR); and Bo-Bae Seo, Seoul (KR)
Assigned to Nexgel Biotech Co. Ltd, Hanam-si (KR)
Filed by Nexgel Biotech Co., Ltd, Hanam-si (KR)
Filed on Aug. 6, 2020, as Appl. No. 16/986,507.
Claims priority of application No. 10-2019-0156759 (KR), filed on Nov. 29, 2019.
Prior Publication US 2021/0163691 A1, Jun. 3, 2021
Int. Cl. C08G 79/025 (2016.01); A61L 27/18 (2006.01); A61L 27/52 (2006.01); B33Y 70/10 (2020.01); B33Y 80/00 (2015.01)
CPC C08G 79/025 (2013.01) [A61L 27/18 (2013.01); A61L 27/52 (2013.01); B33Y 70/10 (2020.01); B33Y 80/00 (2014.12); C08G 2210/00 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A composition, comprising:
an aqueous solvent;
a polyphosphazene-based polymer selected from the group consisting of:
poly[(isoleucine ethyl ester)1.45(aminomethoxypolyethylene glycol 750)0.32(aminoethanol)0.23phosphazene]n,
poly[(isoleucine ethyl ester)1.70(aminomethoxypolyethylene glycol 1000)0.20(aminoethanol)0.10phosphazene]n,
poly[(isoleucine ethyl ester)1.48(aminomethoxypolyethylene glycol 750)0.33(aminoethylsuccinate)0.19phosphazene]n,
poly[(isoleucine ethyl ester)1.70(aminomethoxypolyethylene glycol 1000)0.20(aminoethylsuccinate)0.10phosphazene]n,
poly[(isoleucine ethyl ester)1.38(aminomethoxypolyethylene glycol 750)0.38(aminoethylglutarate)0.24phosphazene]n,
poly[(isoleucine ethyl ester)1.61(aminomethoxypolyethylene glycol 1000)0.22(aminoethylglutarate)0.17phosphazene]n,
poly[(isoleucine ethyl ester)1.48(aminomethoxypolyethylene glycol 750)0.34(aminoethylglutaratebeta-cyclodextrin)0.18phosphazene]n,
poly[(isoleucine ethyl ester)1.51(aminomethoxypolyethylene glycol 750)0.25(aminoethyladipate)0.24phosphazene]n,
poly[(isoleucine ethyl ester)1.40(aminomethoxypolyethylene glycol 750)0.30(aminoethylsulfate)0.30phosphazene]n,
poly[(isoleucine ethyl ester)1.40(aminomethoxypolyethylene glycol 750)0.30(aminoethylmethacrylate)0.30phosphazene]n,
poly[(isoleucine ethyl ester)1.55(aminomethoxypolyethylene glycol 750)0.38(aminoethylsuccinateimidazole)0.07phosphazene]n, and
poly[(isoleucine ethyl ester)1.51(aminomethoxypolyethylene glycol 750)0.40(aminoethylsuccinateCRRRRHHHHHHGGGGGRGDS)0.09phosphazene]n,
wherein n is an integer of 3 to 100,000,
wherein “CRRRRHHHHHHGGGGGRGDS” of the poly[(isoleucine ethyl ester)1.51(aminomethoxypolyethylene glycol 750)0.40(aminoethylsuccinateCRRRRHHHHHHGGGGGRGDS)0.09phosphazene]n is an amino acid sequence.