US 12,168,718 B2
Thermogelling supramolecular sponge as self-healing and biocompatible hydrogel
Thomas Lorson, Guentersleben (DE); and Robert Luxenhofer, Wuerzburg (DE)
Assigned to Julius-Maximilians-Universitaet Wuerzburg, Wuerzburg (DE)
Filed by JULIUS-MAXIMILIANS—UNIVERSITAET WUERZBURG, Wuerzburg (DE)
Filed on Jun. 15, 2021, as Appl. No. 17/348,157.
Application 17/348,157 is a continuation of application No. 16/253,897, filed on Jan. 22, 2019, abandoned.
Application 16/253,897 is a continuation of application No. PCT/EP2017/062982, filed on May 30, 2017.
Claims priority of application No. 16180838 (EP), filed on Jul. 22, 2016.
Prior Publication US 2021/0317267 A1, Oct. 14, 2021
Int. Cl. C08G 73/02 (2006.01); A61K 47/59 (2017.01); A61L 27/18 (2006.01); A61L 27/38 (2006.01); A61L 27/44 (2006.01); C08J 3/075 (2006.01)
CPC C08G 73/0233 (2013.01) [A61K 47/59 (2017.08); A61L 27/18 (2013.01); A61L 27/38 (2013.01); A61L 27/44 (2013.01); C08J 3/075 (2013.01); C08J 2379/02 (2013.01); C08J 2379/04 (2013.01)] 20 Claims
 
1. A thermoresponsive hydrogel comprising an aqueous solution of a block copolymer having a general chemical structure of one of the following formulas:
[A]n-[B]m or [B]n-[A]m
wherein block [A] of the block copolymer is chosen from the group consisting of 2-n-propyl-2-oxazine, 2-cyclopropyl-2-oxazine, and 2-butyl-2-oxazine, wherein block [B] of the block copolymer is chosen from the group consisting of 2-methyl-2-oxazoline and 2-ethyl-2-oxazoline,
wherein n is in the range of 20 to 300, wherein m is in the range of 20 to 300, and wherein n and m have the same or approximately the same value, and
wherein the block copolymer is at a concentration of at least 18 wt. % in the aqueous solution to form the thermoresponsive hydrogel.