US 12,168,084 B2
Extracellular matrix (ECM) structures for tissue regeneration
Robert G. Matheny, Norcross, GA (US)
Assigned to Elutia Med LLC, Silver Spring, MD (US)
Filed by Elutia Med LLC, Silver Spring, MD (US)
Filed on Jan. 14, 2022, as Appl. No. 17/576,633.
Application 17/576,633 is a continuation of application No. 16/418,063, filed on May 21, 2019, abandoned.
Application 16/418,063 is a continuation of application No. 14/685,714, filed on Apr. 14, 2015, granted, now 10,293,084, issued on May 21, 2019.
Application 14/685,714 is a continuation of application No. 14/306,368, filed on Jun. 17, 2014, granted, now 9,333,277, issued on May 10, 2016.
Application 14/306,368 is a continuation of application No. 13/033,102, filed on Feb. 23, 2011, granted, now 8,758,448, issued on Jun. 24, 2014.
Application 13/033,102 is a continuation of application No. 12/394,914, filed on Feb. 27, 2009, abandoned.
Application 12/394,914 is a continuation of application No. 11/747,004, filed on May 10, 2007, abandoned.
Prior Publication US 2022/0211907 A1, Jul. 7, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 27/54 (2006.01); A61F 2/00 (2006.01); A61F 2/02 (2006.01); A61L 27/22 (2006.01); A61L 27/34 (2006.01); A61L 27/36 (2006.01); A61L 27/38 (2006.01); A61L 27/50 (2006.01); A61L 31/00 (2006.01); A61L 31/04 (2006.01); A61L 31/14 (2006.01); A61L 31/16 (2006.01); A61N 1/375 (2006.01); A61K 35/12 (2015.01); A61K 35/22 (2015.01); A61K 35/37 (2015.01); A61K 35/38 (2015.01); A61K 35/42 (2015.01); A61K 38/00 (2006.01); A61K 38/18 (2006.01)
CPC A61L 27/3629 (2013.01) [A61F 2/0077 (2013.01); A61F 2/02 (2013.01); A61L 27/227 (2013.01); A61L 27/34 (2013.01); A61L 27/3604 (2013.01); A61L 27/362 (2013.01); A61L 27/3625 (2013.01); A61L 27/3633 (2013.01); A61L 27/38 (2013.01); A61L 27/3804 (2013.01); A61L 27/3834 (2013.01); A61L 27/50 (2013.01); A61L 27/54 (2013.01); A61L 31/005 (2013.01); A61L 31/041 (2013.01); A61L 31/14 (2013.01); A61L 31/16 (2013.01); A61N 1/375 (2013.01); A61N 1/3752 (2013.01); A61F 2002/0086 (2013.01); A61F 2210/0076 (2013.01); A61K 35/12 (2013.01); A61K 35/22 (2013.01); A61K 35/37 (2013.01); A61K 35/38 (2013.01); A61K 35/42 (2013.01); A61K 38/005 (2013.01); A61K 38/1825 (2013.01); A61L 27/3679 (2013.01); A61L 27/3683 (2013.01); A61L 2300/20 (2013.01); A61L 2300/23 (2013.01); A61L 2300/25 (2013.01); A61L 2300/252 (2013.01); A61L 2300/40 (2013.01); A61L 2300/404 (2013.01); A61L 2300/406 (2013.01); A61L 2300/41 (2013.01); A61L 2300/412 (2013.01); A61L 2300/414 (2013.01); A61L 2300/418 (2013.01); A61L 2300/434 (2013.01); A61L 2300/45 (2013.01); A61L 2300/64 (2013.01); A61L 2400/02 (2013.01); A61L 2400/12 (2013.01); A61L 2400/18 (2013.01); A61L 2430/20 (2013.01)] 16 Claims
 
1. An article comprising:
a bioremodelable pouch structure comprising an extracellular matrix (ECM) structure in sheet form, said ECM structure comprising ECM from a decellularized mammalian tissue source, said decellularized mammalian tissue source being small intestine submucosa, liver basement membrane, stomach submucosa, urinary bladder submucosa, placental basement membrane, pancreatic basement membrane, large intestine submucosa, lung interstitial membrane, respiratory tract submucosa, heart extracellular matrix, or dermal matrix;
said pouch structure comprising an internal cavity having an opening;
wherein the ECM structure provides tensile strength to support newly forming tissue and includes first and second ECM sheets or sheet portions, each ECM sheet or sheet portion having single or plural layers and edges, wherein only the edges of the ECM sheets or sheet portions are joined together by laminating, suturing or gluing except for the edges that form the opening to provide the internal cavity that is located between the sheets or sheet portions; and
wherein the pouch structure is configured to contain an additional component or a composition.