CPC A61K 31/53 (2013.01) [A61K 31/616 (2013.01); A61K 45/06 (2013.01); C07D 495/14 (2013.01); C07D 513/14 (2013.01); C07D 515/14 (2013.01)] | 19 Claims |
1. A compound of Formula (I):
![]() or a pharmaceutically acceptable salt thereof wherein:
R1 is H, halo, or methyl;
R2 is ethyl substituted with —OH, C1-C4alkoxy, or with one or more halo groups; or
R2 is C3-C6alkyl optionally substituted with OH, halo or C1-4alkoxy; or
R2 is C3-C6cycloalkyl;
R3 is C2-C8alkyl optionally substituted with 1 to 3 substituents independently selected from —NH2, —NH(C1-C4alkyl), —NHC(O)O(C1-C4alkyl), —NHC(O)(C1-C4alkyl), —OH, C1-C4alkoxy, haloC1-C4alkoxy, halo and C3-C5cycloalkyl which is further optionally substituted with OH or halo; or
R3 is C3-C10cycloalkyl or C3-C5cycloalkyl-CH2, each of which is optionally substituted with 1 to 3 substituents independently selected from —OH, C1-C4alkyl, C3-C6cycloalkyl, halo, —OC(O)(C1-C4alkyl), haloC1-C4alkyl, —C(O)O(C1-C4alkyl), hydroxyC1-C4alkyl, C1-C4alkoxy, haloC1-C4alkoxy, —NH2, —NH(C1-C4alkyl), —CO2H; or
R3 is mono or bicyclic aryl, or a mono or bicyclic heteroaryl, each of which is optionally substituted with 1 to 3 substituents independently selected from —OH, C1-C4alkyl, C3-C6cycloalkyl, halo, —OC(O)(C1-C4alkyl), haloC1-C4alkyl, —C(O)O(C1-C4alkyl), hydroxyC1-C4alkyl, C1-C4alkoxy, haloC1-C4alkoxy, —NH2, —SO2NH2, —SO2NH(C1-C4alkyl), —NHSO2(C1-C4alkyl), —NH(C1-C4alkyl), —C(O)NH2, C(O)C1-C4alkyl, —CO2H; or
R3 is a mono or bicyclic heterocyclyl optionally substituted with 1 to 3 substituents independently selected from —OH, oxo, C3-C6cycloalkyl, halo, —C(O)O—C1-C4alkyl, —C(O)C1-C4alkyl, and C1-C4alkyl which is further optionally substituted with 1 to 4 substituents independently selected from C3-C6cycloalkyl, halo, C1-C4alkoxy, haloC1-C4alkoxy and OH;
X is N or CH.
|