CPC A61K 31/519 (2013.01) [A61K 9/0075 (2013.01); A61K 9/1682 (2013.01)] | 25 Claims |
1. A method for producing a sterile liquid pharmaceutical composition comprising sterile ensifentrine particles suitable for administration by inhalation, the method comprising:
(a) heating ensifentrine particles at a temperature of from 100° C. to 220° C. to obtain the sterile ensifentrine particles, wherein the heating produces less than a 0.5% w/w increase in total impurities; and
(b) combining the sterile ensifentrine particles with a sterile liquid vehicle to produce the sterile liquid pharmaceutical composition suitable for administration by inhalation.
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