US 12,169,205 B2
Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use
Yoshinao Ruike, Singapore (SG); Taichi Kuramochi, Singapore (SG); Hiroyasu Muramatsu, Shizuoka (JP); Atsunori Ueyama, Shizuoka (JP); Tomoyuki Igawa, Shizuoka (JP); Hitoshi Katada, Shizuoka (JP); and Yuji Hori, Shizuoka (JP)
Assigned to CHUGAI SEIYAKU KABUSHIKI KAISHA, Tokyo (JP)
Filed by Chugai Seiyaku Kabushiki Kaisha, Tokyo (JP)
Filed on Apr. 26, 2018, as Appl. No. 15/963,455.
Application 15/963,455 is a division of application No. 14/974,488, filed on Dec. 18, 2015, granted, now 10,000,560.
Claims priority of application No. 2014-257636 (JP), filed on Dec. 19, 2014.
Prior Publication US 2018/0319877 A1, Nov. 8, 2018
Int. Cl. G01N 33/68 (2006.01); A61K 39/00 (2006.01); C07K 16/22 (2006.01)
CPC G01N 33/6872 (2013.01) [C07K 16/22 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/33 (2013.01); C07K 2317/34 (2013.01); C07K 2317/52 (2013.01); C07K 2317/565 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01); C12N 2510/02 (2013.01); G01N 2333/495 (2013.01)] 5 Claims
 
1. A polypeptide comprising a variant Fc region, wherein the variant Fc region comprises amino acid alterations in a parent Fc region at positions 234, 238, 264, 311, 330, and 343 according to EU numbering, wherein the parent Fc region comprises the amino acid sequence of any one of SEQ ID NO: 195-197, or 198, and wherein the variant Fc region comprises an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 195-197, or 198, respectively.