US 12,170,153 B2
Systems and techniques for calibrating radioisotope delivery systems with a gamma detector
Adrian Nunn, Lambertville, NJ (US)
Assigned to Bracco Diagnostics Inc., Monroe Township, NJ (US)
Appl. No. 17/042,353
Filed by BRACCO DIAGNOSTICS INC., Monroe Township, NJ (US)
PCT Filed Mar. 28, 2019, PCT No. PCT/US2019/024512
§ 371(c)(1), (2) Date Sep. 28, 2020,
PCT Pub. No. WO2019/191384, PCT Pub. Date Oct. 3, 2019.
Claims priority of provisional application 62/649,368, filed on Mar. 28, 2018.
Prior Publication US 2021/0012917 A1, Jan. 14, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. G21G 1/00 (2006.01); A61B 6/58 (2024.01); A61B 50/13 (2016.01); A61M 5/00 (2006.01); A61M 5/142 (2006.01); A61N 5/10 (2006.01); G01T 1/161 (2006.01); G01T 7/02 (2006.01); G16H 20/17 (2018.01); G21G 4/08 (2006.01); A61M 39/22 (2006.01); G21H 5/02 (2006.01)
CPC G21G 1/0005 (2013.01) [A61B 6/582 (2013.01); A61B 50/13 (2016.02); A61M 5/007 (2013.01); A61M 5/142 (2013.01); A61N 5/1007 (2013.01); G01T 1/161 (2013.01); G01T 7/02 (2013.01); G16H 20/17 (2018.01); G21G 4/08 (2013.01); A61M 39/223 (2013.01); A61M 2205/50 (2013.01); A61M 2205/70 (2013.01); G21H 5/02 (2013.01)] 31 Claims
OG exemplary drawing
 
1. An infusion system comprising:
a frame that carries a beta detector, a gamma detector, and a controller communicatively coupled to the beta detector and the gamma detector,
wherein the frame is further configured to receive a strontium-rubidium radioisotope generator that generates a radioactive eluate via elution,
the beta detector is positioned to measure beta emissions emitted from the radioactive eluate,
the gamma detector is positioned to measure gamma emissions emitted from the radioactive eluate, and
the controller is configured to determine an activity of the radioactive eluate based on the beta emissions measured by the beta detector, determine an activity of the radioactive eluate based on the gamma emissions measured by the gamma detector, and calibrate the infusion system based on comparison of the activity of the radioactive eluate measured by the beta detector to the activity of the radioactive eluate measured by the gamma detector.