US 12,168,114 B2
Fluid delivery device having an insertable prefilled cartridge
Christopher C. Gregory, Newtown, PA (US); Matthew P. Johnson, Boylston, MA (US); and Robert L. Standley, Acton, MA (US)
Assigned to MannKind Corporation, Danbury, CT (US)
Filed by MannKind Corporation, Danbury, CT (US)
Filed on Apr. 5, 2023, as Appl. No. 18/296,162.
Application 18/296,162 is a continuation of application No. 16/783,609, filed on Feb. 6, 2020, granted, now 11,660,387.
Application 16/783,609 is a continuation of application No. 14/786,009, granted, now 10,596,313, issued on Mar. 24, 2020, previously published as PCT/US2014/040205, filed on May 30, 2014.
Claims priority of provisional application 61/923,957, filed on Jan. 6, 2014.
Claims priority of provisional application 61/918,746, filed on Dec. 20, 2013.
Claims priority of provisional application 61/857,415, filed on Jul. 23, 2013.
Claims priority of provisional application 61/829,325, filed on May 31, 2013.
Prior Publication US 2023/0233758 A1, Jul. 27, 2023
Int. Cl. A61M 5/142 (2006.01); A61M 5/14 (2006.01); A61M 5/145 (2006.01); A61M 5/158 (2006.01); A61M 5/162 (2006.01); A61M 5/28 (2006.01)
CPC A61M 5/14248 (2013.01) [A61M 5/14526 (2013.01); A61M 5/288 (2013.01); A61M 5/1407 (2013.01); A61M 2005/14252 (2013.01); A61M 2005/1426 (2013.01); A61M 2005/14268 (2013.01); A61M 5/1452 (2013.01); A61M 2005/1585 (2013.01); A61M 5/162 (2013.01); A61M 2005/1623 (2013.01)] 7 Claims
OG exemplary drawing
 
1. A fluid delivery device comprising:
a housing having a bottom surface configured to be coupled to a skin surface, the housing including a hydraulic fluid drive containing a hydraulic fluid, the hydraulic fluid drive including a first hydraulic chamber and a second hydraulic chamber, the first hydraulic chamber being fluidly coupled to the second hydraulic chamber by a flow restrictor;
a cartridge prefilled with a fluid and configured to be inserted into the housing, the cartridge having a septum; and
a needle assembly having a needle including a fluid coupling end and a delivery end, the fluid coupling end of the needle being fluidly disengaged from the cartridge in an initial position, the delivery end of the needle extending past a plane co-planar with the bottom surface in a deployed position and the fluid coupling end of the needle extending through the septum in the deployed position,
wherein the hydraulic fluid drive includes a port configured to couple with the cartridge, the port having a seal that is closed prior to inserting the cartridge into the housing and released when the cartridge is coupled with the port, the cartridge including a piston moveable by the hydraulic fluid when the needle is in the deployed position,
wherein the seal includes a slideable valve having one or more fluid passages configured to fluidly couple the hydraulic fluid drive and the piston.
 
4. A fluid delivery device comprising:
a housing having a bottom surface configured to be coupled to a skin surface, the housing including a hydraulic fluid drive containing a hydraulic fluid, the hydraulic fluid drive including a first hydraulic chamber and a second hydraulic chamber, the first hydraulic chamber being fluidly coupled to the second hydraulic chamber by a flow restrictor;
a cartridge prefilled with a fluid and configured to be inserted into the housing, the cartridge having a septum; and
a needle assembly having a needle including a fluid coupling end and a delivery end, the fluid coupling end of the needle being fluidly disengaged from the cartridge in an initial position, the delivery end of the needle extending past a plane co-planar with the bottom surface in a deployed position and the fluid coupling end of the needle extending through the septum in the deployed position,
wherein the hydraulic fluid drive includes a port configured to couple with the cartridge, the port having a seal that is closed prior to inserting the cartridge into the housing and released when the cartridge is coupled with the port, the cartridge including a piston moveable by the hydraulic fluid when the needle is in the deployed position,
wherein the hydraulic fluid drive is fluidly coupled to an accumulator configured to allow thermal expansion and contraction of the hydraulic fluid.
 
6. A fluid delivery device comprising:
a housing having a bottom surface configured to be coupled to a skin surface, the housing including a hydraulic fluid drive containing a hydraulic fluid, the hydraulic fluid drive including a first hydraulic chamber and a second hydraulic chamber, the first hydraulic chamber being fluidly coupled to the second hydraulic chamber by a flow restrictor;
a cartridge prefilled with a fluid and configured to be inserted into the housing, the cartridge having a septum; and
a needle assembly having a needle including a fluid coupling end and a delivery end, the fluid coupling end of the needle being fluidly disengaged from the cartridge in an initial position, the delivery end of the needle extending past a plane co-planar with the bottom surface in a deployed position and the fluid coupling end of the needle extending through the septum in the deployed position,
wherein the hydraulic fluid drive includes a port configured to couple with the cartridge, the port having a seal that is closed prior to inserting the cartridge into the housing and released when the cartridge is coupled with the port, the cartridge including a piston moveable by the hydraulic fluid when the needle is in the deployed position,
wherein the port includes a ball joint receiver that is at an acute angle relative to the bottom surface of the housing until the cartridge is retained in place relative to the housing.
 
7. A fluid delivery device comprising:
a housing having a bottom surface configured to be coupled to a skin surface, the housing including a hydraulic fluid drive containing a hydraulic fluid, the hydraulic fluid drive including a first hydraulic chamber and a second hydraulic chamber, the first hydraulic chamber being fluidly coupled to the second hydraulic chamber by a flow restrictor;
a cartridge prefilled with a fluid and configured to be inserted into the housing, the cartridge having a septum; and
a needle assembly having a needle including a fluid coupling end and a delivery end, the fluid coupling end of the needle being fluidly disengaged from the cartridge in an initial position, the delivery end of the needle extending past a plane co-planar with the bottom surface in a deployed position and the fluid coupling end of the needle extending through the septum in the deployed position,
wherein the hydraulic fluid drive includes a port configured to couple with the cartridge, the port having a seal that is closed prior to inserting the cartridge into the housing and released when the cartridge is coupled with the port, the cartridge including a piston moveable by the hydraulic fluid when the needle is in the deployed position,
wherein the piston includes a spike configured to pierce the seal when the cartridge is coupled with the port.